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线性纳米级保罗阱中的长 DNA 片段。

A long DNA segment in a linear nanoscale Paul trap.

机构信息

Physics Division, Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831, USA.

出版信息

Nanotechnology. 2010 Jan 8;21(1):015103. doi: 10.1088/0957-4484/21/1/015103. Epub 2009 Nov 30.

Abstract

We study the dynamics of a linearly distributed line charge such as single stranded DNA (ssDNA) in a nanoscale, linear 2D Paul trap in vacuum. Using molecular dynamics simulations we show that a line charge can be trapped effectively in the trap for a well defined range of stability parameters. We investigated (i) a flexible bonded string of charged beads and (ii) a ssDNA polymer of variable length, for various trap parameters. A line charge undergoes oscillations or rotations as it moves, depending on its initial angle, the position of the center of mass and the velocity. The stability region for a strongly bonded line of charged beads is similar to that of a single ion with the same charge to mass ratio. Single stranded DNA as long as 40 nm does not fold or curl in the Paul trap, but could undergo rotations about the center of mass. However, we show that a stretching field in the axial direction can effectively prevent the rotations and increase the confinement stability.

摘要

我们研究了线性分布线电荷(如单链 DNA(ssDNA))在真空中的纳米级线性 2D Paul 陷阱中的动力学。使用分子动力学模拟,我们表明,在定义明确的稳定参数范围内,可以有效地将线电荷捕获在陷阱中。我们研究了(i)带电荷珠的柔性键合字符串和(ii)具有不同长度的 ssDNA 聚合物,针对各种陷阱参数。线电荷在移动时会发生振荡或旋转,具体取决于其初始角度、质心位置和速度。带电荷珠的强键线的稳定区域与具有相同电荷质量比的单个离子相似。长达 40nm 的单链 DNA 不会在 Paul 陷阱中折叠或卷曲,但可以围绕质心旋转。然而,我们表明,轴向拉伸场可以有效地防止旋转并提高约束稳定性。

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