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Rheumatoid arthritis: the multifaceted role of adiponectin in inflammatory joint disease.

作者信息

Müller-Ladner Ulf, Neumann Elena

出版信息

Nat Rev Rheumatol. 2009 Dec;5(12):659-60. doi: 10.1038/nrrheum.2009.232.

DOI:10.1038/nrrheum.2009.232
PMID:19946293
Abstract
摘要

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Rheumatoid arthritis: the multifaceted role of adiponectin in inflammatory joint disease.类风湿性关节炎：脂联素在炎性关节疾病中的多方面作用
Nat Rev Rheumatol. 2009 Dec;5(12):659-60. doi: 10.1038/nrrheum.2009.232.
2
Disease-modifying antirheumatic drugs increase serum adiponectin levels in patients with rheumatoid arthritis.改善病情的抗风湿药物可增加类风湿关节炎患者的血清脂联素水平。
J Clin Rheumatol. 2011 Jan;17(1):14-7. doi: 10.1097/RHU.0b013e318204a587.
3
Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis.类风湿关节炎患者血浆中脂源性激素脂联素、瘦素、抵抗素和内脂素水平的变化。
Ann Rheum Dis. 2006 Sep;65(9):1198-201. doi: 10.1136/ard.2005.046540. Epub 2006 Jan 13.
4
Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction.血清脂联素浓度与通过关节破坏程度评估的类风湿性关节炎严重程度相关。
Clin Rheumatol. 2009 Apr;28(4):445-51. doi: 10.1007/s10067-008-1074-y. Epub 2008 Dec 16.
5
Increased adiponectin is negatively linked to the local inflammatory process in patients with rheumatoid arthritis.脂联素水平升高与类风湿关节炎患者的局部炎症过程呈负相关。
Cytokine. 2006 Sep;35(5-6):247-52. doi: 10.1016/j.cyto.2006.09.002. Epub 2006 Oct 31.
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Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis.抵抗素、瘦素和脂联素的血清水平升高与类风湿关节炎中的C反应蛋白以及其他临床状况相关。
Intern Med. 2011;50(4):269-75. doi: 10.2169/internalmedicine.50.4306. Epub 2011 Feb 15.
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Association Between Adiponectin and Clinical Manifestations in Rheumatoid Arthritis.脂联素与类风湿关节炎临床表现的相关性。
J Interferon Cytokine Res. 2020 Oct;40(10):501-508. doi: 10.1089/jir.2020.0080. Epub 2020 Aug 25.
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Response to 'Serum level of adiponectin is a surrogate independent biomarker of radiographic disease progression in early rheumatoid arthritis: results from the ESPOIR cohort'- authors' reply.
Arthritis Res Ther. 2014;16(2):407. doi: 10.1186/ar4537. Epub 2014 Apr 10.
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Response to 'Serum level of adiponectin is a surrogate independent biomarker of radiographic disease progression in early rheumatoid arthritis: results from the ESPOIR cohort' - authors' reply.对《血清脂联素水平是早期类风湿关节炎影像学疾病进展的替代独立生物标志物：ESPOIR队列研究结果》的回应——作者回复
Arthritis Res Ther. 2014;16(2):408. doi: 10.1186/ar4538. Epub 2014 Apr 10.
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Plasma adiponectin in patients with active, early, and chronic rheumatoid arthritis who are steroid- and disease-modifying antirheumatic drug-naive compared with patients with osteoarthritis and controls.与骨关节炎患者及对照组相比，未使用过类固醇和改善病情抗风湿药物的活动期、早期及慢性类风湿关节炎患者的血浆脂联素水平。
J Rheumatol. 2009 Sep;36(9):1885-91. doi: 10.3899/jrheum.080907. Epub 2009 Aug 14.

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Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants.素食 4 周后血浆瘦素和脂联素的变化：一项健康参与者的随机对照试验
Int J Environ Res Public Health. 2022 Sep 9;19(18):11370. doi: 10.3390/ijerph191811370.
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Early Prediction of Clinical Response to Etanercept Treatment in Juvenile Idiopathic Arthritis Using Machine Learning.

本文引用的文献

1
Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis.脂联素是肥胖与类风湿关节炎影像学损伤之间负相关关系的一种介质。
Arthritis Rheum. 2009 Sep 15;61(9):1248-56. doi: 10.1002/art.24789.
2
Plasma adiponectin in patients with active, early, and chronic rheumatoid arthritis who are steroid- and disease-modifying antirheumatic drug-naive compared with patients with osteoarthritis and controls.与骨关节炎患者及对照组相比，未使用过类固醇和改善病情抗风湿药物的活动期、早期及慢性类风湿关节炎患者的血浆脂联素水平。
J Rheumatol. 2009 Sep;36(9):1885-91. doi: 10.3899/jrheum.080907. Epub 2009 Aug 14.
3
使用机器学习对幼年特发性关节炎患者依那西普治疗的临床反应进行早期预测
Front Pharmacol. 2020 Jul 31;11:1164. doi: 10.3389/fphar.2020.01164. eCollection 2020.
4
Body mass index and treatment survival in patients with RA starting treatment with TNFα-inhibitors: long-term follow-up in the real-life METEOR registry.体重指数与开始接受 TNFα 抑制剂治疗的 RA 患者的治疗结局：真实世界 METEOR 注册研究的长期随访。
RMD Open. 2020 Jun;6(2). doi: 10.1136/rmdopen-2020-001203.
5
Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis.血清脂联素作为类风湿关节炎患者对抗肿瘤坏死因子-α治疗实验室反应的预测指标
Cent Eur J Immunol. 2018;43(3):289-294. doi: 10.5114/ceji.2018.80048. Epub 2018 Oct 30.
6
Body mass index and response to tocilizumab in rheumatoid arthritis: a real life study.体重指数与类风湿关节炎患者对托珠单抗的反应：一项真实世界研究
Clin Rheumatol. 2016 Apr;35(4):857-61. doi: 10.1007/s10067-016-3183-3. Epub 2016 Jan 22.
7
A Prospective Follow-Up of Adipocytokines in Cohort Patients With Gout: Association With Metabolic Syndrome But Not With Clinical Inflammatory Findings: Strobe-Compliant Article.痛风队列患者脂肪细胞因子的前瞻性随访：与代谢综合征相关，但与临床炎症表现无关：符合STROBE标准的文章
Medicine (Baltimore). 2015 Jul;94(26):e935. doi: 10.1097/MD.0000000000000935.
8
Obesity as a risk and severity factor in rheumatic diseases (autoimmune chronic inflammatory diseases).肥胖作为风湿性疾病（自身免疫性慢性炎症性疾病）的风险和严重程度因素。
Front Immunol. 2014 Nov 11;5:576. doi: 10.3389/fimmu.2014.00576. eCollection 2014.
9
[Adiponectin as target in rheumatoid arthritis].[脂联素作为类风湿关节炎的治疗靶点]
Z Rheumatol. 2014 Aug;73(6):556-8. doi: 10.1007/s00393-013-1325-4.
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Ethnic-specific genetic analyses in rheumatoid arthritis: incremental gains but valuable contributions to the big picture.类风湿关节炎的种族特异性基因分析：虽有渐进性进展，但对整体情况有重要贡献。
Arthritis Rheum. 2013 Dec;65(12):3014-6. doi: 10.1002/art.38111.
Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway.
脂联素通过丝裂原活化蛋白激酶（MAPK）信号通路刺激人成骨细胞中核因子κB受体活化因子配体（RANKL）的表达并抑制骨保护素（OPG）的表达。
J Bone Miner Res. 2006 Oct;21(10):1648-56. doi: 10.1359/jbmr.060707.
4
The potential of adiponectin in driving arthritis.
J Immunol. 2006 Apr 1;176(7):4468-78. doi: 10.4049/jimmunol.176.7.4468.
5
Different effects of adiponectin isoforms in human monocytic cells.脂联素亚型在人单核细胞中的不同作用。
J Leukoc Biol. 2006 Apr;79(4):803-8. doi: 10.1189/jlb.0905521. Epub 2006 Jan 24.
6
Adiponectin and adiponectin receptors.脂联素与脂联素受体。
Endocr Rev. 2005 May;26(3):439-51. doi: 10.1210/er.2005-0005.
7
Adiponectin--journey from an adipocyte secretory protein to biomarker of the metabolic syndrome.脂联素——从脂肪细胞分泌蛋白到代谢综合征生物标志物的历程。
J Intern Med. 2005 Feb;257(2):167-75. doi: 10.1111/j.1365-2796.2004.01426.x.
8
Adiponectin: A novel adipokine linking adipocytes and vascular function.脂联素：一种连接脂肪细胞与血管功能的新型脂肪因子。
J Clin Endocrinol Metab. 2004 Jun;89(6):2563-8. doi: 10.1210/jc.2004-0518.
9
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans.脂肪组织衍生细胞因子对脂联素的调节：人体的体内和体外研究
Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E527-33. doi: 10.1152/ajpendo.00110.2003. Epub 2003 May 7.
10
A novel serum protein similar to C1q, produced exclusively in adipocytes.一种仅在脂肪细胞中产生的类似于C1q的新型血清蛋白。
J Biol Chem. 1995 Nov 10;270(45):26746-9. doi: 10.1074/jbc.270.45.26746.