State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
J Zhejiang Univ Sci B. 2009 Dec;10(12):920-7. doi: 10.1631/jzus.B0920279.
To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted.
We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 -174 G/C and -572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 -6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well.
The present meta-analysis indicates that the IL-6 -174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And -572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.
为了阐明白细胞介素 6 (IL-6)多态性与牙周炎的关系,进行了病例对照研究的荟萃分析和系统评价。
我们在 2009 年 5 月前使用 PubMed 和 Medline 数据库进行文献检索,未作任何限制。我们还查阅了所有检索到的文章的参考文献。选择了 6 项病例对照研究,共纳入 1093 例牙周炎患者和 574 例对照,进行荟萃分析以评估 IL-6 多态性与牙周炎风险之间的关联。本荟萃分析纳入了 IL-6-174 G/C 和-572 C/G 多态性,并对 IL-6-6331 T/C 多态性与牙周炎风险的关系进行了充分评价。
本荟萃分析表明,IL-6-174 G 等位基因不能改变慢性牙周炎的风险,但增加了侵袭性牙周炎的风险。-572 C/G 多态性与牙周炎的发病机制有关,包括慢性牙周炎或侵袭性牙周炎。