Chatzopoulos Georgios S, Doufexi Aikaterini-Ellisavet, Zarenti Sofia, Anastasopoulos Menelaos, Kouvatsi Anastasia
Division of Periodontology, Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.
Private practice limited to Periodontics and Implant Dentistry, Thessaloniki, Greece.
Acta Stomatol Croat. 2020 Sep;54(3):238-249. doi: 10.15644/asc54/3/2.
The aim of this study was to investigate whether genetic susceptibility to chronic periodontitis, conferred by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele, influences the outcomes following a non-surgical periodontal therapy (NSPT)over a long period of time.
Thirty-seven chronic periodontitis patients were divided into two groups according to genotype as susceptible (SCP) and non-susceptible (NSCP). All subjects were clinically evaluated at baseline and 3 years following NSPT. Blood samples were collected at baseline from the individuals who fulfilled the inclusion criteria. All participants received NSPT from a single periodontist who was blind to the genotype status of each patient. A statistical analysis was performed by comparing the variables between groups using the Mann-Whitney U test and between baseline and 3 years for each group using the Wilcoxon test.
The mean age of the population was estimated to be 47.68±8.64 years and it included 51.4% females, 48.6% smokers, and 45.9% alcohol consumers. Following a genetic analysis, 70.3% of patients were homozygous carriers of the IL-6 -572G (IL-6 SCP), and 46.0% of them were carriers of the IL-10 -592A allele (IL-10 SCP). NSPT reduced all studied parameters (probing depth, attachment loss, bleeding on probing, percentage of sites with 4-6mm and ≥7mm pocket depth and attachment loss) to all participants, but the treatment outcome was not associated with the genotype. The SCP and NSCP individuals showed similar clinical parameters at baseline and at 3 years.
Within the limitations of this 3-year prospective cohort study in Caucasians diagnosed with chronic periodontitis, individuals susceptible to periodontal disease as determined by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele showed similar treatment outcome following NSPT.
本研究旨在调查由白细胞介素6（IL-6）-572GG基因型或白细胞介素10（IL-10）-592A等位基因导致的慢性牙周炎遗传易感性是否会长期影响非手术牙周治疗（NSPT）的效果。
37例慢性牙周炎患者根据基因型分为易感组（SCP）和非易感组（NSCP）。所有受试者在基线和NSPT后3年进行临床评估。从符合纳入标准的个体中在基线时采集血样。所有参与者均由一位对每位患者的基因型状态不知情的单一牙周病医生进行NSPT治疗。使用曼-惠特尼U检验比较组间变量，并使用威尔科克森检验比较每组基线和3年之间的变量，进行统计分析。
人群的平均年龄估计为47.68±8.64岁，其中女性占51.4%，吸烟者占48.6%，饮酒者占45.9%。经过基因分析，70.3%的患者是IL-6 -572G的纯合携带者（IL-6 SCP），其中46.0%是IL-10 -592A等位基因的携带者（IL-10 SCP）。NSPT使所有参与者的所有研究参数（探诊深度、附着丧失、探诊出血、4 - 6mm和≥7mm牙周袋深度及附着丧失部位的百分比）均降低，但治疗效果与基因型无关。SCP和NSCP个体在基线和3年时显示出相似的临床参数。
在这项针对诊断为慢性牙周炎的高加索人的3年前瞻性队列研究的局限性内，由IL-6 -572GG基因型或IL-10 -592A等位基因确定的牙周病易感个体在NSPT后显示出相似的治疗效果。
