测试药物对小鼠衰老和寿命影响的方法。

Methods of testing pharmacological drugs effects on aging and life span in mice.

作者信息

Anisimov Vladimir N, Popovich Irina G, Zabezhinski Mark A

机构信息

Department of Carcinogenesis and Oncogerontology, NN Petrov Research Institute of Oncology, St. Petersburg, Russia.

出版信息

Methods Mol Biol. 2013;1048:145-60. doi: 10.1007/978-1-62703-556-9_12.

DOI:10.1007/978-1-62703-556-9_12

PMID:23929104

Abstract

The methodology of testing antiaging drugs in laboratory mice is presented. It is based on more than 40-year-long authors' experience in the field and includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment of biomarkers of aging, life-span parameters, pathology examination, and statistical treatment of the results.

摘要

介绍了在实验室小鼠中测试抗衰老药物的方法。它基于作者在该领域40多年的经验，包括小鼠品系的选择、性别、治疗开始时的年龄、饲养条件、长期研究的设计、一些评估衰老生物标志物的非侵入性方法、寿命参数、病理检查以及结果的统计处理。