[牛血清白蛋白修饰的氧化铁纳米颗粒的制备及特性]

[Preparation and characteristics of iron oxide nanoparticles modified by bovine serum albumin].

作者信息

Zhao Peng, Weng Jie, Hou Peng

机构信息

Key Laboratory of Materials Advanced Technologies (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Oct;26(5):1005-9.

PMID:19947478

Abstract

Ultrafine iron oxide nanoparticles were prepared in aqueous solution using chemical coprecipitation method. Adsorption of bovine serum albumin (BSA) on magnetic particles was studied in the presence of silane coupling KH550. Characterizations of magnetic particles were carried out by X-ray diffraction, Transmission electron microscopy, Fourier transform infrared spectrometer and vibrating-sample magnetometer. The experimental results showed that magnetic nanoparticles were well dispersed with a small decrease of the magnetic saturation after modification. Magnetic nanoparticles wrapped in KH550 were favorable to the adsorption of BSA while the capability of hydrophile increased consequently, which could be used for target carrier in biomedicine.

摘要

采用化学共沉淀法在水溶液中制备了超细微氧化铁纳米粒子。在硅烷偶联剂KH550存在的条件下，研究了牛血清白蛋白（BSA）在磁性颗粒上的吸附情况。通过X射线衍射、透射电子显微镜、傅里叶变换红外光谱仪和振动样品磁强计对磁性颗粒进行了表征。实验结果表明，磁性纳米粒子分散良好，改性后磁饱和度略有下降。包裹有KH550的磁性纳米粒子有利于BSA的吸附，亲水性也随之增强，可用于生物医学中的靶向载体。