Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.
Eur J Vasc Endovasc Surg. 2010 Feb;39(2):200-7. doi: 10.1016/j.ejvs.2009.10.014. Epub 2009 Nov 30.
The aim of this review is to delineate the association between abdominal aortic aneurysms (AAAs) and diabetes mellitus. Mechanisms for the underlying association are then discussed.
A systematic review of the English-language literature using PubMed, EMBASE and Cochrane databases was undertaken up to September 2009. Studies reporting appropriate prevalence data were identified and a meta-analysis performed.
Eleven studies were identified. The prevalence of diabetes mellitus in studied patients with AAA ranged from 6% to 14%. The prevalence of diabetes in control patients without AAA ranged from 17% to 36%. Pooled analysis suggested a reduced rate of diabetes amongst people with AAA compared to those without (OR 0.65, 0.60-0.70, p<0.001).
Studies so far suggest a protective role for diabetes on the development of AAA. Further research is required to demarcate the underlying mechanisms for this possible association.
本文旨在阐述腹主动脉瘤（AAA）与糖尿病之间的关联。随后将讨论其潜在的关联机制。
我们对截至 2009 年 9 月 Pubmed、EMBASE 和 Cochrane 数据库中的英文文献进行了系统性回顾，以确定有合适流行率数据的研究，并进行了荟萃分析。
共发现 11 项研究。患有 AAA 的研究患者中糖尿病的患病率为 6%-14%。无 AAA 的对照组患者中糖尿病的患病率为 17%-36%。合并分析表明，与无 AAA 的人群相比，AAA 患者中糖尿病的发生率较低（OR 0.65，0.60-0.70，p<0.001）。
目前的研究表明，糖尿病对 AAA 的发生有保护作用。需要进一步的研究来确定这种可能关联的潜在机制。
