糖尿病与腹主动脉瘤。
Diabetes and the abdominal aortic aneurysm.
机构信息
Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.
出版信息
Eur J Vasc Endovasc Surg. 2010 Feb;39(2):200-7. doi: 10.1016/j.ejvs.2009.10.014. Epub 2009 Nov 30.
OBJECTIVE
The aim of this review is to delineate the association between abdominal aortic aneurysms (AAAs) and diabetes mellitus. Mechanisms for the underlying association are then discussed.
METHODS
A systematic review of the English-language literature using PubMed, EMBASE and Cochrane databases was undertaken up to September 2009. Studies reporting appropriate prevalence data were identified and a meta-analysis performed.
RESULTS
Eleven studies were identified. The prevalence of diabetes mellitus in studied patients with AAA ranged from 6% to 14%. The prevalence of diabetes in control patients without AAA ranged from 17% to 36%. Pooled analysis suggested a reduced rate of diabetes amongst people with AAA compared to those without (OR 0.65, 0.60-0.70, p<0.001).
CONCLUSIONS
Studies so far suggest a protective role for diabetes on the development of AAA. Further research is required to demarcate the underlying mechanisms for this possible association.
目的
本文旨在阐述腹主动脉瘤（AAA）与糖尿病之间的关联。随后将讨论其潜在的关联机制。
方法
我们对截至 2009 年 9 月 Pubmed、EMBASE 和 Cochrane 数据库中的英文文献进行了系统性回顾，以确定有合适流行率数据的研究，并进行了荟萃分析。
结果
共发现 11 项研究。患有 AAA 的研究患者中糖尿病的患病率为 6%-14%。无 AAA 的对照组患者中糖尿病的患病率为 17%-36%。合并分析表明，与无 AAA 的人群相比，AAA 患者中糖尿病的发生率较低（OR 0.65，0.60-0.70，p<0.001）。
结论
目前的研究表明，糖尿病对 AAA 的发生有保护作用。需要进一步的研究来确定这种可能关联的潜在机制。
Zotero 插件