Whyatt Robin M, Adibi Jennifer J, Calafat Antonia M, Camann David E, Rauh Virgina, Bhat Hari K, Perera Frederica P, Andrews Howard, Just Allan C, Hoepner Lori, Tang Deliang, Hauser Russ
Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Pediatrics. 2009 Dec;124(6):e1213-20. doi: 10.1542/peds.2009-0325.
Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City.
Forty-eight-hour personal air and/or spot urine samples were collected during the third trimester. DEHP levels were measured in air samples and 4 DEHP metabolite levels were measured in urine. Specific gravity was used to adjust for urinary dilution. Gestational age was abstracted from newborn medical records (n = 289) or calculated from the expected date of delivery (n = 42). Multivariate linear regression models controlled for potential confounders.
DEHP was detected in 100% of personal air samples (geometric mean: 0.20 microg/m(3) [95% confidence interval [CI]: 0.18-0.21 microg/m(3)]); natural logarithms of air concentrations were inversely but not significantly associated with gestational age. Two or more of the DEHP metabolites were detected in 100% of urine samples (geometric mean: 4.8-38.9 ng/mL [95% CI: 4.1-44.3 ng/mL]). Controlling for potential confounders, gestational age was shorter by 1.1 days (95% CI: 0.2-1.8 days) for each 1-logarithmic unit increase in specific gravity-adjusted mono(2-ethylhexyl)phthalate concentrations (P = .01) and averaged 5.0 days (95% CI: 2.1-8.0 days) less among subjects with the highest versus lowest quartile concentrations (P = .001). Results were similar and statistically significant for the other DEHP metabolites.
Prenatal DEHP exposure was associated with shorter gestation but, given inconsistencies with previous findings for other study populations, results should be interpreted with caution, and additional research is warranted.
我们的目的是评估纽约市311名非裔美国或多米尼加女性孕期邻苯二甲酸二（2-乙基己基）酯（DEHP）暴露与分娩时孕周之间的关系。
孕晚期收集48小时个人空气和/或随机尿样。测量空气样本中的DEHP水平以及尿样中的4种DEHP代谢物水平。用比重校正尿液稀释情况。孕周从新生儿病历中提取（n = 289）或根据预计分娩日期计算（n = 42）。采用多变量线性回归模型控制潜在混杂因素。
100%的个人空气样本中检测到DEHP（几何均值：0.20微克/立方米[95%置信区间[CI]：0.18 - 0.21微克/立方米]）；空气浓度的自然对数与孕周呈负相关，但无显著关联。100%的尿样中检测到两种或更多种DEHP代谢物（几何均值：4.8 - 38.9纳克/毫升[95% CI：4.1 - 44.3纳克/毫升]）。控制潜在混杂因素后，比重校正后的单（2-乙基己基）邻苯二甲酸酯浓度每增加1个对数单位，孕周缩短1.1天（95% CI：0.2 - 1.8天）（P = 0.01），四分位数浓度最高组与最低组相比，孕周平均短5.0天（95% CI：2.1 - 8.0天）（P = 0.001）。其他DEHP代谢物的结果相似且具有统计学意义。
产前DEHP暴露与较短孕周有关，但鉴于与其他研究人群先前的研究结果不一致，应谨慎解释结果，且有必要进行更多研究。
