检测基因间转换的方法的威力。
The power of the methods for detecting interlocus gene conversion.
机构信息
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan.
出版信息
Genetics. 2010 Feb;184(2):517-27. doi: 10.1534/genetics.109.111161. Epub 2009 Nov 30.
Abstract
Interlocus gene conversion can homogenize DNA sequences of duplicated regions with high homology. Such nonvertical events sometimes cause a misleading evolutionary interpretation of data when the effect of gene conversion is ignored. To avoid this problem, it is crucial to test the data for the presence of gene conversion. Here, we performed extensive simulations to compare four major methods to detect gene conversion. One might expect that the power increases with increase of the gene conversion rate. However, we found this is true for only two methods. For the other two, limited power is expected when gene conversion is too frequent. We suggest using multiple methods to minimize the chance of missing the footprint of gene conversion.
摘要
基因座间基因转换可以使具有高度同源性的重复区域的 DNA 序列同质化。当忽略基因转换的影响时，这种非垂直事件有时会导致对数据的误导性进化解释。为避免此问题，测试数据中是否存在基因转换至关重要。在这里，我们进行了广泛的模拟，以比较四种主要的基因转换检测方法。人们可能期望随着基因转换率的增加，功效也会增加。但是，我们发现只有两种方法是正确的。对于另外两种方法，当基因转换过于频繁时，预期功效会受到限制。我们建议使用多种方法来最小化错过基因转换痕迹的机会。
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