Donohoe Owen, Zhang Haiyan, Delrez Natacha, Gao Yuan, Suárez Nicolás M, Davison Andrew J, Vanderplasschen Alain
Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, B-4000 Liège, Belgium.
Bioscience Research Institute, Athlone Institute of Technology, Athlone, Co. N37 HD68 Westmeath, Ireland.
Microorganisms. 2021 May 5;9(5):998. doi: 10.3390/microorganisms9050998.
Anguillid herpesvirus 1 (AngHV-1) is a pathogen of eels and a member of the genus in the family . We have compared the biological and genomic features of different AngHV-1 strains, focusing on their growth kinetics in vitro and genetic content, diversity, and recombination. Comparisons based on three core genes conserved among alloherpesviruses revealed that AngHV-1 exhibits a slower rate of change and less positive selection than other cypriniviruses. We propose that this may be linked to major differences in host species and corresponding epidemiological circumstances. Efforts to derive evolutionary rate estimates for cypriniviruses under various theoretical models were ultimately unrewarding. We highlight the potential value of future collaborative efforts towards generating short-term evolutionary rate estimates based on known sequence sampling dates. Finally, we revealed that there is significantly less genetic diversity in core gene sequences within cyprinivirus species clades compared to species in the family . This suggests that cyprinivirus species may have undergone much more vigorous purifying selection post species clade divergence. We discuss whether this may be linked to biological and anthropogenic factors or to sampling bias, and we propose that the comparison of short-term evolutionary rates between species may provide further insights into these differences.
鳗鲡疱疹病毒1（AngHV-1）是鳗鱼的一种病原体，属于某科某属的成员。我们比较了不同AngHV-1毒株的生物学和基因组特征，重点关注它们在体外的生长动力学以及遗传内容、多样性和重组情况。基于在异疱疹病毒中保守的三个核心基因进行的比较表明，与其他鲤疱疹病毒相比，AngHV-1的变化速率较慢且正向选择较少。我们认为这可能与宿主物种的主要差异以及相应的流行病学情况有关。在各种理论模型下推导鲤疱疹病毒进化速率估计值的努力最终没有取得成果。我们强调了未来基于已知序列采样日期进行短期进化速率估计的合作努力的潜在价值。最后，我们发现与某科的物种相比，鲤疱疹病毒物种分支内核心基因序列的遗传多样性显著更低。这表明鲤疱疹病毒物种在物种分支分化后可能经历了更为强烈的纯化选择。我们讨论了这是否可能与生物学和人为因素或采样偏差有关，并提出物种间短期进化速率的比较可能会为这些差异提供进一步的见解。
