Nagao H, Morimoto T, Sano N, Takahashi M, Nagai H, Tawa R, Yoshimatsu M, Woo Y J, Matsuda H
Department of Pathology for the Handicapped, Faculty of Education, Ehime University.
No To Hattatsu. 1991 Jan;23(1):39-43.
Magnetic resonance imaging of skeletal muscles in thirteen patients with Duchenne muscular dystrophy was performed to estimate pathological changes. Serial axial and sagittal sections of the right lower extremity were recorded. In the early stage, the T1 values of gastrocnemius and soleus muscles were slightly lower than the control values, and in the late stage, the values were much lower in all muscles examined. In sagittal sections, the gastrocnemius muscles in the early stage showed a high density area at the distal region adjacent to soleus muscle, and the soleus muscle showed a high density area adjacent to the gestrocnemius muscle. In serial axial sections, high density areas of the anterior and posterior tibialis muscles appeared first at their proximal and peripheral regions. It was concluded that the sequence of appearance of pathological changes was different not only among individual muscles but also among various regions of each muscle; the high density changes appeared first at myotendon junctions.
对13例杜氏肌营养不良患者的骨骼肌进行磁共振成像，以评估病理变化。记录了右下肢的系列轴向和矢状面图像。在疾病早期，腓肠肌和比目鱼肌的T1值略低于对照值，而在疾病后期，所有检查肌肉的T1值均显著降低。在矢状面图像中，疾病早期腓肠肌在比目鱼肌相邻的远端区域呈现高密度区，比目鱼肌在与腓肠肌相邻处也呈现高密度区。在系列轴向图像中，胫前肌和胫后肌的高密度区首先出现在其近端和周边区域。研究得出结论，不仅不同肌肉之间，而且每块肌肉的不同区域之间，病理变化的出现顺序都不同；高密度变化首先出现在肌腱连接处。
