Matsumura K, Nakano I, Fukuda N, Ikehira H, Tateno Y, Aoki Y
Department of Neurology, Shimoshizu National Hospital, Chiba, Japan.
Muscle Nerve. 1988 Feb;11(2):97-102. doi: 10.1002/mus.880110202.
By means of proton MRI, the spin-lattice relaxation times (T1 values) of pelvic and leg muscles were measured in Duchenne muscular dystrophy (DMD) patients and normal controls. The bound water fraction (BWF) was calculated from the T1 value obtained. In normal children, the T1 value decreased, and BWF increased with age. In DMD, the T1 value rapidly decreased, from an abnormally high value in the early stages, with the progress of the disease. This reduction of the T1 value in DMD was not the same for all muscles; it was most prominent in the gluteus maximus and least prominent in the sartorius and gracilis muscles. BWF was below normal in the early stages of DMD. It is suggested that both regenerating and degenerating muscle fibers, together with the increased muscle water content, cause the high T1 value and low BWF in the early stages of DMD, whereas replacement of muscle by fat causes the decreased T1 value in the advanced stages.
通过质子磁共振成像（MRI），对杜氏肌营养不良症（DMD）患者和正常对照者的骨盆及腿部肌肉的自旋晶格弛豫时间（T1值）进行了测量。根据所获得的T1值计算结合水分数（BWF）。在正常儿童中，T1值随年龄降低，BWF随年龄增加。在DMD患者中，随着疾病进展，T1值从早期的异常高值迅速降低。DMD患者中T1值的这种降低在所有肌肉中并不相同；在臀大肌中最为明显，在缝匠肌和股薄肌中最不明显。DMD早期BWF低于正常水平。提示在DMD早期，再生和退变的肌纤维以及增加的肌肉含水量导致T1值升高和BWF降低，而在疾病晚期，肌肉被脂肪替代导致T1值降低。
