Matsumura K, Nakano I, Fukuda N, Ikehira H, Tateno Y, Aoki Y
Department of Neurology, Shimoshizu National Hospital, Chiba, Japan.
Neuroradiology. 1989;31(5):373-6. doi: 10.1007/BF00343858.
By means of magnetic resonance imaging (MRI), the proton spin-lattice relaxation times (T1 values) of the skeletal muscles were measured in Duchenne muscular dystrophy (DMD) carriers and normal controls. The bound water fraction (BWF) was calculated form the T1 values obtained, according to the fast proton diffusion model. In the DMD carriers, T1 values of the gluteus maximus and quadriceps femoris muscles were significantly higher, and BWFs of these muscles were significantly lower, than in normal control. Degenerative muscular changes accompanied by interstitial edema were presumed responsible for this abnormality. No correlation was observed between the muscle T1 and serum creatine kinase values. The present study showed that MRI could be a useful method for studying the dynamic state of water in both normal and pathological skeletal muscles. Its possible utility for DMD carrier detection was discussed briefly.
通过磁共振成像（MRI），测量了杜兴氏肌营养不良症（DMD）携带者和正常对照者骨骼肌的质子自旋-晶格弛豫时间（T1值）。根据快速质子扩散模型，从获得的T1值计算结合水分数（BWF）。在DMD携带者中，臀大肌和股四头肌的T1值显著更高，而这些肌肉的BWF显著更低，与正常对照相比。推测伴有间质水肿的退行性肌肉变化是导致这种异常的原因。未观察到肌肉T1与血清肌酸激酶值之间的相关性。本研究表明，MRI可能是研究正常和病理状态下骨骼肌中水的动态状态的有用方法。简要讨论了其在检测DMD携带者方面的潜在用途。
