Hearing and Speech Department, University of Kansas Medical Center, Kansas City, 66160-7605, USA.
Int J Audiol. 2009 Nov;48(11):811-9. doi: 10.3109/14992020903019338.
ECochG has long been shown to complement the diagnosis of MD, primarily through measurement of the SP/AP amplitude ratio. While reported in the literature to be highly specific to this disorder, ECochG's sensitivity in the general MD population remains relatively low (ranging from 20-65%). The current study assessed the sensitivity and specificity of the ECochG protocol we employ for suspected MD patients, which includes measuring both the amplitudes and areas of the SP and AP to clicks (to derive the SP/AP amplitude and area ratios), and the SP amplitudes to 1000 and 2000 Hz tone bursts. A retrospective chart review was conducted to compare ECochG results from 178 suspected MD patients with their eventual diagnoses. Measurements of highest sensitivity and specificity (determined using a logistic regression analysis) included: SP amplitude, SP area, SP/AP area ratio, and total SP-AP area. Sensitivity and specificity values associated with these measures were 92% and 84%, respectively. The sensitivity value is considerably higher than previously reported, and is attributable to the inclusion of area measurements in our protocol.
电声耳镜检查（EcochG）长期以来一直被证明可以辅助 MD 的诊断，主要通过测量 SP/AP 幅度比。尽管文献报道该检查对这种疾病具有高度特异性，但在一般 MD 人群中的敏感性仍然相对较低（范围为 20-65%）。本研究评估了我们用于疑似 MD 患者的 EcochG 方案的敏感性和特异性，该方案包括测量 SP 和 AP 对 click 的幅度和面积（以推导出 SP/AP 幅度和面积比），以及 SP 幅度对 1000Hz 和 2000Hz 声爆发的反应。进行了回顾性图表审查，以比较 178 例疑似 MD 患者的 EcochG 结果与其最终诊断。使用逻辑回归分析确定的具有最高敏感性和特异性的测量值包括：SP 幅度、SP 面积、SP/AP 面积比和总 SP-AP 面积。这些指标的敏感性和特异性值分别为 92%和 84%。该敏感性值明显高于之前的报道，这归因于我们方案中包含了面积测量。
