风疹抗体水平与细胞介导免疫的细胞因子测量值之间的相关性。
Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity.
机构信息
Mayo Vaccine Research Group, Mayo Clinic , Rochester, Minnesota 55905, USA.
出版信息
Viral Immunol. 2009 Dec;22(6):451-6. doi: 10.1089/vim.2009.0068.
Abstract
Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.
摘要
尽管有安全有效的疫苗，但地方性风疹在发展中国家仍然是一个问题。在疫苗覆盖率高的地区，可能会出现散发病例和暴发。未接种疫苗或未产生血清转换的个人，尤其是孕妇，容易受到感染，其婴儿有患先天性风疹综合征（CRS）的风险。体液和细胞免疫反应都有助于免疫保护。传统上，通过检测风疹特异性抗体滴度来评估对风疹的免疫力。在这项研究中，我们在明尼苏达州奥姆斯特德县的一大群免疫接种的年轻成年人中检查了体液和细胞免疫的相关性。我们未能发现体外风疹刺激后细胞因子产生与血清抗体滴度之间存在任何显著相关性。
相似文献
1
Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity.风疹抗体水平与细胞介导免疫的细胞因子测量值之间的相关性。
Viral Immunol. 2009 Dec;22(6):451-6. doi: 10.1089/vim.2009.0068.
2
Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.四个不同队列中对风疹疫苗的体液免疫和细胞免疫特征
Immunol Res. 2014 Jan;58(1):1-8. doi: 10.1007/s12026-013-8475-y.
3
Correlations among measles virus-specific antibody, lymphoproliferation and Th1/Th2 cytokine responses following measles-mumps-rubella-II (MMR-II) vaccination.麻疹-腮腺炎-风疹联合疫苗（MMR-II）接种后麻疹病毒特异性抗体、淋巴细胞增殖及Th1/Th2细胞因子反应之间的相关性
Clin Exp Immunol. 2005 Dec;142(3):498-504. doi: 10.1111/j.1365-2249.2005.02931.x.
4
Rubella virus-specific humoral immune responses and their interrelationships before and after a third dose of measles-mumps-rubella vaccine in women of childbearing age.风疹病毒特异性体液免疫应答及其在育龄妇女接种麻疹-腮腺炎-风疹疫苗第三剂前后的相互关系。
Vaccine. 2020 Jan 29;38(5):1249-1257. doi: 10.1016/j.vaccine.2019.11.004. Epub 2019 Nov 12.
5
Rubella specific cell-mediated and humoral immunity following vaccination in college students with low antibody titers.抗体滴度较低的大学生接种疫苗后风疹特异性细胞免疫和体液免疫
Vaccine. 2015 Nov 9;33(45):6093-8. doi: 10.1016/j.vaccine.2015.06.113. Epub 2015 Aug 12.
6
Assessment of immune status against measles, mumps, and rubella in young Kuwaitis: MMR vaccine efficacy.评估科威特年轻人对麻疹、腮腺炎和风疹的免疫状态：MMR 疫苗的效力。
J Med Virol. 2020 Aug;92(8):963-970. doi: 10.1002/jmv.25665. Epub 2020 Feb 3.
7
Transcriptional signatures associated with rubella virus-specific humoral immunity after a third dose of MMR vaccine in women of childbearing age.风疹病毒特异性体液免疫后，育龄妇女第三次接种 MMR 疫苗的转录特征。
Eur J Immunol. 2021 Jul;51(7):1824-1838. doi: 10.1002/eji.202049054. Epub 2021 Apr 19.
8
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.麻疹-腮腺炎-风疹疫苗接种者中全基因组单核苷酸多态性与风疹特异性细胞因子反应的关联。
Immunogenetics. 2014 Aug;66(7-8):493-9. doi: 10.1007/s00251-014-0776-3. Epub 2014 May 9.
9
Associations between markers of cellular and humoral immunity to rubella virus following a third dose of measles-mumps-rubella vaccine.接种麻疹-腮腺炎-风疹疫苗第三剂后风疹病毒细胞和体液免疫标志物的相关性。
Vaccine. 2020 Nov 25;38(50):7897-7904. doi: 10.1016/j.vaccine.2020.10.071. Epub 2020 Nov 4.
10
Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus-Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination.Wilms 瘤基因多态性与麻疹-腮腺炎-风疹二联疫苗接种后风疹病毒特异性细胞免疫的个体间差异相关。
J Infect Dis. 2018 Jan 30;217(4):560-566. doi: 10.1093/infdis/jix538.
引用本文的文献
1
Serosurveillance for Measles and Rubella.麻疹和风疹血清学监测
Vaccines (Basel). 2024 Jul 22;12(7):816. doi: 10.3390/vaccines12070816.
2
Associations between markers of cellular and humoral immunity to rubella virus following a third dose of measles-mumps-rubella vaccine.接种麻疹-腮腺炎-风疹疫苗第三剂后风疹病毒细胞和体液免疫标志物的相关性。
Vaccine. 2020 Nov 25;38(50):7897-7904. doi: 10.1016/j.vaccine.2020.10.071. Epub 2020 Nov 4.
3
T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders.T 淋巴细胞作为针对病毒疾病的保护和疫苗接种的可衡量靶标。
Int Rev Cell Mol Biol. 2019;342:175-263. doi: 10.1016/bs.ircmb.2018.07.006. Epub 2018 Oct 24.
4
Characterization of rubella-specific humoral immunity following two doses of MMR vaccine using proteome microarray technology.使用蛋白质组芯片技术对两剂麻疹-腮腺炎-风疹疫苗接种后的风疹特异性体液免疫进行表征。
PLoS One. 2017 Nov 16;12(11):e0188149. doi: 10.1371/journal.pone.0188149. eCollection 2017.
5
High-throughput assay optimization and statistical interpolation of rubella-specific neutralizing antibody titers.风疹特异性中和抗体滴度的高通量检测优化及统计插值法
Clin Vaccine Immunol. 2014 Mar;21(3):340-6. doi: 10.1128/CVI.00681-13. Epub 2014 Jan 3.
6
Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.四个不同队列中对风疹疫苗的体液免疫和细胞免疫特征
Immunol Res. 2014 Jan;58(1):1-8. doi: 10.1007/s12026-013-8475-y.
7
Associations between demographic variables and multiple measles-specific innate and cell-mediated immune responses after measles vaccination.麻疹疫苗接种后麻疹特异性固有和细胞介导免疫反应的人口统计学变量之间的关联。
Viral Immunol. 2012 Feb;25(1):29-36. doi: 10.1089/vim.2011.0051. Epub 2012 Jan 12.
8
Correlations between vaccinia-specific immune responses within a cohort of armed forces members.在一个武装部队成员队列中，痘苗特异性免疫应答的相关性。
Viral Immunol. 2011 Oct;24(5):415-20. doi: 10.1089/vim.2011.0029. Epub 2011 Sep 29.
9
Correlates of protection induced by vaccination.疫苗接种诱导的保护相关性。
Clin Vaccine Immunol. 2010 Jul;17(7):1055-65. doi: 10.1128/CVI.00131-10. Epub 2010 May 12.
本文引用的文献
1
Long-term humoral and cellular immune response to hepatitis B vaccine in high-risk children 18-20 years after neonatal immunization.高危儿童新生儿免疫接种18 - 20年后对乙肝疫苗的长期体液免疫和细胞免疫反应
Viral Immunol. 2009 Apr;22(2):125-30. doi: 10.1089/vim.2008.0087.
2
Response surface methodology to determine optimal cytokine responses in human peripheral blood mononuclear cells after smallpox vaccination.采用响应面法确定天花疫苗接种后人外周血单个核细胞中的最佳细胞因子反应。
J Immunol Methods. 2009 Feb 28;341(1-2):97-105. doi: 10.1016/j.jim.2008.11.001. Epub 2008 Nov 25.
3
Analysis of gene expression in fetal and adult cells infected with rubella virus.风疹病毒感染的胎儿和成人细胞中的基因表达分析。
Virology. 2008 Jan 5;370(1):1-11. doi: 10.1016/j.virol.2007.08.003. Epub 2007 Oct 24.
4
The relevance of cytokines for development of protective immunity and rational design of vaccines.细胞因子在保护性免疫发展及疫苗合理设计中的相关性。
Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):195-207. doi: 10.1016/j.cytogfr.2007.01.016. Epub 2007 Mar 7.
5
Murine cytokine patterns following rubella vaccination.
Iran J Allergy Asthma Immunol. 2003 Jun;2(2):89-93.
6
Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination.健康个体接种风疹疫苗后HLA多态性与γ干扰素及白细胞介素-10细胞因子产生之间的关系。
Clin Vaccine Immunol. 2007 Feb;14(2):115-22. doi: 10.1128/CVI.00247-06. Epub 2007 Jan 10.
7
Detection of measles virus-specific interferon-gamma-secreting T-cells by ELISPOT.通过酶联免疫斑点法检测麻疹病毒特异性干扰素-γ分泌性T细胞。
Methods Mol Biol. 2005;302:207-18. doi: 10.1385/1-59259-903-6:207.
8
Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults.老年人中流感疫苗单剂量与加强剂量对体液免疫和细胞免疫反应的比较。
Vaccine. 2005 May 9;23(25):3294-300. doi: 10.1016/j.vaccine.2005.01.080.
9
The contribution of HLA class I antigens in immune status following two doses of rubella vaccination.两剂风疹疫苗接种后HLA I类抗原在免疫状态中的作用。
Hum Immunol. 2004 Dec;65(12):1506-15. doi: 10.1016/j.humimm.2004.07.001.
10
Rubella and congenital rubella syndrome: global update.风疹与先天性风疹综合征：全球最新情况
Rev Panam Salud Publica. 2003 Nov;14(5):306-15. doi: 10.1590/s1020-49892003001000005.
Zotero 插件