Servicio de Inmunología, Hospital Reina Sofía, 14004 Córdoba, Spain.
Viral Immunol. 2009 Dec;22(6):463-5. doi: 10.1089/vim.2009.0041.
It has been recently reported that CD8(+) T cells from healthy human peripheral blood express the tolerogenic HLA-G molecule originally described in trophoblasts. The majority of these CD8(+)HLA-G(+) cells exhibit a naïve phenotype and are FoxP3 negative, and they have been classified as a novel subset of regulatory T cells based on their potent suppressive function. We have investigated if this new cell population is expanded during HIV-1 infection. The results presented here show an increase in the percentage of CD8(+)HLA-G(+) cells within the total CD8 T-cell population in HIV-1(+) patients. As in healthy controls, these CD8(+)HLA-G(+) are mostly naïve T cells. However, we have also observed that only in HIV-1-infected patients are there effector and effector memory cells that express HLA-G.
最近有报道称，健康人外周血中的 CD8(+)T 细胞表达最初在滋养层细胞中描述的耐受性 HLA-G 分子。这些 CD8(+)HLA-G(+)细胞中的大多数表现出幼稚表型，FoxP3 阴性，并且根据其强大的抑制功能被归类为新型调节性 T 细胞亚群。我们研究了在 HIV-1 感染期间是否会扩增这种新的细胞群。本文介绍的结果表明，HIV-1(+)患者的总 CD8 T 细胞群中 CD8(+)HLA-G(+)细胞的百分比增加。与健康对照组一样，这些 CD8(+)HLA-G(+)细胞主要是幼稚 T 细胞。然而，我们还观察到，只有在 HIV-1 感染的患者中才存在表达 HLA-G 的效应和效应记忆细胞。
