免疫介导疾病中的 HLA-G 表达免疫细胞。
HLA-G Expressing Immune Cells in Immune Mediated Diseases.
机构信息
Department of Internal Medicine, University of Genoa, Genoa, Italy.
出版信息
Front Immunol. 2020 Aug 28;11:1613. doi: 10.3389/fimmu.2020.01613. eCollection 2020.
Abstract
HLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G-expressing CD4+ and CD8+ T lymphocytes, NK cells, monocytes, and dendritic cells with immunoregulatory functions are present in small percentages of patients with physiologic conditions. Quantitative and qualitative derangements of HLA-G+ immune cells have been detected in several conditions in which the immune system plays an important role, such as infectious, neoplastic, and autoimmune diseases as well as in complications from transplants and pregnancy. These observations strongly support the hypothesis that HLA-G+ immune cells may be implicated in the complex mechanisms underlying the pathogenesis of these disorders.
摘要
人类白细胞抗原 G（HLA-G）是一种 HLA 类 Ib 抗原，具有免疫调节特性。在生理条件下的小部分患者中，存在具有免疫调节功能的 HLA-G 表达的 CD4+和 CD8+T 淋巴细胞、NK 细胞、单核细胞和树突状细胞。在免疫系统发挥重要作用的几种情况下，如感染、肿瘤和自身免疫性疾病，以及移植和妊娠并发症中，已经检测到 HLA-G+免疫细胞的定量和定性紊乱。这些观察结果强烈支持这样一种假设，即 HLA-G+免疫细胞可能与这些疾病发病机制中的复杂机制有关。
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Nat Immunol. 2020 Jun;21(6):605-614. doi: 10.1038/s41590-020-0677-6. Epub 2020 May 4.
2
Expression of membrane-bound human leucocyte antigen-G in systemic sclerosis and systemic lupus erythematosus.
Hum Immunol. 2020 Apr;81(4):162-167. doi: 10.1016/j.humimm.2019.12.004. Epub 2019 Dec 14.
3
Brain immunology and immunotherapy in brain tumours.
Nat Rev Cancer. 2020 Jan;20(1):12-25. doi: 10.1038/s41568-019-0224-7. Epub 2019 Dec 5.
4
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.
Int J Mol Sci. 2019 Oct 29;20(21):5372. doi: 10.3390/ijms20215372.
5
Novel paradigms in systemic lupus erythematosus.
Lancet. 2019 Jun 8;393(10188):2344-2358. doi: 10.1016/S0140-6736(19)30546-X. Epub 2019 Jun 6.
6
Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis.
J Rheumatol. 2020 Mar;47(3):377-386. doi: 10.3899/jrheum.181232. Epub 2019 May 15.
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Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10).
Cell Mol Immunol. 2020 Jan;17(1):95-107. doi: 10.1038/s41423-019-0218-0. Epub 2019 Mar 6.
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