中国一家三级医院非结构性心脏病心房颤动患者的代谢综合征。

Metabolic syndrome in patients with atrial fibrillation in the absence of structural heart disease from a tertiary hospital in China.

机构信息

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

出版信息

Chin Med J (Engl). 2009 Nov 20;122(22):2744-7.

PMID:19951607

Abstract

BACKGROUND

Metabolic syndrome (MetS) and atrial fibrillation (AF) are causally related. This study aimed to determine the prevalence of MetS in patients with AF in the absence of structural heart disease from a tertiary hospital in China.

METHODS

In a single center, 741 inpatients with AF in the absence of structural heart disease prior to catheter ablation were retrospectively reviewed. Among them, 588 (79.4%) patients had paroxysmal AF. Subgroup analyses were performed in paroxysmal AF and persistent/permanent AF.

RESULTS

MetS was found in 343 (46.3%) patients (200 males, 143 females); 0, 1, 2, 3, 4, 5 components of the MetS were found in 59 (8.0%), 140 (18.9%), 199 (26.9%), 203 (27.4%), 103 (13.9%) and 37 (5.0%) patients, respectively. The prevalences of overweight/obesity, high blood pressure, high glucose level, high triglyceride level and low high density lipoproteins cholesterol level were 53.8%, 47.6%, 23.2%, 40.6% and 72.1%, respectively. The prevalence of MetS was not significantly different between the paroxysmal AF group and the persistent/permanent AF group (44.6% vs 52.9%, P = 0.064). The five components of MetS except overweight/obesity (69.3% vs 49.8%, P < 0.001) were not significantly different between the aforementioned two groups. The left atrium diameter increased with the sum of the MetS components. The left atrium diameter in the MetS group was significantly higher than that in the non-MetS group both in patients with paroxysmal AF and in patients with persistent/permanent AF.

CONCLUSIONS

The prevalence of MetS in patients with AF prior to catheter ablation is high. Further study and prevention are needed.

摘要

背景

代谢综合征（MetS）和心房颤动（AF）存在因果关系。本研究旨在确定在中国一家三级医院接受导管消融治疗的无结构性心脏病的 AF 患者中 MetS 的患病率。

方法

在单中心回顾性分析了 741 例无结构性心脏病的 AF 住院患者，其中 588 例（79.4%）为阵发性 AF。在阵发性 AF 和持续性/永久性 AF 中进行了亚组分析。

结果

343 例（46.3%）患者存在 MetS（200 例男性，143 例女性）；0、1、2、3、4、5 个 MetS 成分分别见于 59 例（8.0%）、140 例（18.9%）、199 例（26.9%）、203 例（27.4%）、103 例（13.9%）和 37 例（5.0%）患者。超重/肥胖、高血压、高血糖、高甘油三酯和低高密度脂蛋白胆固醇的患病率分别为 53.8%、47.6%、23.2%、40.6%和 72.1%。阵发性 AF 组和持续性/永久性 AF 组 MetS 的患病率无显著差异（44.6% vs. 52.9%，P = 0.064）。除超重/肥胖（69.3% vs. 49.8%，P < 0.001）外，上述两组的 MetS 五个成分无显著差异。左心房直径随 MetS 成分的总和而增加。在阵发性 AF 和持续性/永久性 AF 患者中，MetS 组的左心房直径均显著高于非 MetS 组。