Department of Cardiology, University Clinical Hospital Centre "Dr Dragisa Misovic" (Tadic), Belgrade, Serbia; Clinic of Cardiology (Ivanovic), Clinical Centre of Serbia, Belgrade, Serbia; Clinical Research Unit (Cuspidi), University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy.
Clin Cardiol. 2013 Nov;36(11):654-62. doi: 10.1002/clc.22163. Epub 2013 Jun 20.
Metabolic syndrome represents a cluster of atherogenic risk factors including hypertension, insulin resistance, obesity, and dyslipidemia. Considering that all of these risk factors could influence the development of atrial fibrillation, an association between atrial fibrillation and the metabolic syndrome has been suggested. Additionally, oxidative stress and inflammation have been involved in the pathogenesis of both metabolic syndrome and atrial fibrillation. The mechanisms that relate metabolic syndrome to the increased risk of atrial fibrillation occurrence are not completely understood. Metabolic syndrome and atrial fibrillation are associated with increased cardiovascular morbidity and mortality. Because atrial fibrillation is the most common arrhythmia, and along with the prevalence of metabolic syndrome constantly increasing, it would be very important to determine the relationship between these 2 entities, especially due to the fact that the risk factors of metabolic syndrome are mainly correctable. This review focused on the available evidence supporting the association between metabolic syndrome components and metabolic syndrome as a clinical entity with atrial fibrillation.
代谢综合征是一组动脉粥样硬化危险因素的聚集，包括高血压、胰岛素抵抗、肥胖和血脂异常。由于所有这些危险因素都可能影响心房颤动的发生，因此有人提出心房颤动与代谢综合征之间存在关联。此外，氧化应激和炎症参与了代谢综合征和心房颤动的发病机制。将代谢综合征与心房颤动发生风险增加相关联的机制尚不完全清楚。代谢综合征和心房颤动与心血管发病率和死亡率增加有关。由于心房颤动是最常见的心律失常，而且随着代谢综合征的患病率不断增加，确定这两者之间的关系非常重要，特别是因为代谢综合征的危险因素主要是可以纠正的。本综述重点介绍了支持代谢综合征各组成部分以及代谢综合征作为一种临床实体与心房颤动之间关联的现有证据。
