Rochester Psychiatric Center, 1111 Elmwood Ave., Rochester, NY 14620, USA.
Psychiatr Serv. 2009 Dec;60(12):1686-9. doi: 10.1176/ps.2009.60.12.1686.
Schizophrenia is associated with significant reductions in life expectancy, largely because of the increased incidence of cardiovascular disease. This study examined the prevalence of metabolic risk factors for cardiovascular disease among Medicaid recipients diagnosed as having schizophrenia and taking second-generation antipsychotics (medications associated with increased risk of metabolic abnormalities contributing to cardiovascular disease).
Fifteen community health centers in King County, Washington, identified 1,317 eligible individuals, of whom 819 completed screenings for obesity, impaired fasting glucose levels or diabetes, hypertension, and dyslipidemia.
Fasting serum levels were obtained for 675 individuals, of whom 90% were diagnosed as having at least one risk factor, with elevated body mass index and dyslipidemia the most prevalent factors. About one-third of the individuals approached to participate did not obtain laboratory work necessary for the screening.
The study indicates that this population has a high rate of metabolic risk of cardiovascular disease and that treatment will require addressing barriers to screening.
精神分裂症与预期寿命的显著缩短有关，这主要是由于心血管疾病发病率的增加。本研究调查了在接受医疗补助并服用第二代抗精神病药物（与代谢异常风险增加相关，这些异常会导致心血管疾病）的精神分裂症患者中，心血管疾病代谢风险因素的流行情况。
华盛顿州金县的 15 个社区卫生中心确定了 1317 名符合条件的个体，其中 819 名完成了肥胖、空腹血糖受损或糖尿病、高血压和血脂异常的筛查。
对 675 名个体进行了空腹血清水平检测，其中 90%的个体被诊断为至少有一种风险因素，其中升高的体重指数和血脂异常是最常见的因素。大约三分之一被邀请参加的个体没有获得筛查所需的实验室检查。
该研究表明，该人群存在较高的心血管疾病代谢风险，治疗将需要解决筛查障碍。
