Webster P D, Black O, Mainz D L, Singh M
Gastroenterology. 1977 Dec;73(6):1434-49.
This review outlines progress made during the past 11 years in research related to pancreatic acinar cell metabolism and function. We have reviewed information gained at the cellular level concerning structural and functional relationships, and effects of fasting and feeding, as well as the action of gastrointestinal hormones and cholinergic agonists on acinar cells. In toto, this information outlines a significant role for gastrointestinal hormones as mediators of secretion, synthesis, and control of trophism. This information provides a basis for more sophisticated inquiries as to the mechanisms of injury of alcohol and drugs. The information may prove helpful in developing diagnostic modalities for pancreatic disease, as well as understanding the processes involved in neoplastic transformation.
本综述概述了过去11年中胰腺腺泡细胞代谢与功能相关研究的进展。我们回顾了在细胞水平上获得的有关结构与功能关系、禁食和进食的影响以及胃肠激素和胆碱能激动剂对腺泡细胞作用的信息。总体而言，这些信息勾勒出胃肠激素作为分泌、合成和营养控制介质的重要作用。这些信息为更深入探究酒精和药物损伤机制提供了基础。这些信息可能有助于开发胰腺疾病的诊断方法，以及理解肿瘤转化所涉及的过程。
