• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

精神分裂症和阿尔茨海默病患者大脑皮质中酪蛋白激酶2水平降低。

The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.

作者信息

Aksenova M V, Burbaeva G S, Kandror K V, Kapkov D V, Stepanov A S

机构信息

All-Union Research Center for Mental Health, USSR Academy of Medical Sciences, Moscow.

出版信息

FEBS Lett. 1991 Feb 11;279(1):55-7. doi: 10.1016/0014-5793(91)80249-3.

DOI:10.1016/0014-5793(91)80249-3
PMID:1995343
Abstract

The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.

摘要

通过免疫印迹法已证实，与正常大脑相比，精神分裂症和阿尔茨海默病患者额叶皮质的无核糖体提取物中酪蛋白激酶2的含量显著降低。在所研究的精神病理学病例中，酪蛋白激酶2对内源性底物和酪蛋白的活性也有所降低。这一现象可能解释了人类大脑结构蛋白磷酸化中众所周知的异常，而这些异常是精神疾病所固有的。

相似文献

1
The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.精神分裂症和阿尔茨海默病患者大脑皮质中酪蛋白激酶2水平降低。
FEBS Lett. 1991 Feb 11;279(1):55-7. doi: 10.1016/0014-5793(91)80249-3.
2
[Cytoplasmic casein kinase 2 and its substrate proteins in the brain in Alzheimer's disease].
Biull Eksp Biol Med. 1992 Jun;113(6):602-3.
3
Phosphorylation of protein B-50 (GAP-43) from adult rat brain cortex by casein kinase II.酪蛋白激酶II对成年大鼠大脑皮层中蛋白B-50（GAP-43）的磷酸化作用。
Biochem Biophys Res Commun. 1988 Sep 30;155(3):1207-12. doi: 10.1016/s0006-291x(88)81268-3.
4
Aberrant casein kinase II in Alzheimer's disease.阿尔茨海默病中异常的酪蛋白激酶II
Brain Res. 1990 Jan 22;507(2):273-80. doi: 10.1016/0006-8993(90)90282-g.
5
Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain.
J Neurochem. 1997 Dec;69(6):2506-15. doi: 10.1046/j.1471-4159.1997.69062506.x.
6
[The detection of cytoplasmic creatinine phosphokinase BB in nerve cell nuclei under normal conditions, in schizophrenia, and in Alzheimer's disease patients].[正常条件下、精神分裂症患者及阿尔茨海默病患者神经细胞核中细胞质肌酸磷酸激酶BB的检测]
Biull Eksp Biol Med. 1993 Feb;115(2):153-5.
7
[Creatine phosphokinase distribution in the brain in schizophrenia and Alzheimer's disease].[精神分裂症和阿尔茨海默病患者大脑中肌酸磷酸激酶的分布]
Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(2):35-6.
8
Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain.阿尔茨海默病和唐氏综合征患者的人脑中有丝分裂原活化蛋白激酶（MAP激酶）活性增加，但精神分裂症患者的人脑并非如此。
Eur J Neurosci. 2004 May;19(10):2711-9. doi: 10.1111/j.0953-816X.2004.03365.x.
9
[Decreased level of creatine phosphokinase BB in the brain of patients with mental disorders (complex immunochemical and immunocytochemical studies)].[精神障碍患者大脑中肌酸磷酸激酶BB水平降低（综合免疫化学和免疫细胞化学研究）]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(10):49-52.
10
Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimer's disease patients and aged controls.晚期阿尔茨海默病患者和老年对照组大脑皮质中的凋亡相关蛋白激酶（DAPK1）。
Neuropathol Appl Neurobiol. 2010 Feb;36(1):17-24. doi: 10.1111/j.1365-2990.2009.01035.x. Epub 2009 Jul 14.

引用本文的文献

1
Protein kinase CK2α' as a dual modulator of neuroimmune signaling and synaptic dysfunction in Tauopathy.蛋白激酶CK2α'作为Tau蛋白病中神经免疫信号和突触功能障碍的双重调节因子。
Res Sq. 2025 Aug 7:rs.3.rs-7078069. doi: 10.21203/rs.3.rs-7078069/v1.
2
Phosphorylation and Dephosphorylation of Beta-Amyloid Peptide in Model Cell Cultures: The Role of Cellular Protein Kinases and Phosphatases.模型细胞培养中β-淀粉样肽的磷酸化与去磷酸化：细胞蛋白激酶和磷酸酶的作用
Life (Basel). 2023 Jan 4;13(1):147. doi: 10.3390/life13010147.
3
Protein kinase CK2: a potential therapeutic target for diverse human diseases.
蛋白激酶 CK2：一种针对多种人类疾病的潜在治疗靶点。
Signal Transduct Target Ther. 2021 May 17;6(1):183. doi: 10.1038/s41392-021-00567-7.
4
Novel rare variations in genes that regulate developmental change in N-methyl-d-aspartate receptor in patients with schizophrenia.精神分裂症患者中调控N-甲基-D-天冬氨酸受体发育变化的基因的新型罕见变异。
Hum Genome Var. 2018 Feb 1;5:17056. doi: 10.1038/hgv.2017.56. eCollection 2018.
5
SlgA, encoded by the homolog of the human schizophrenia-associated gene , acts in clock neurons to regulate aggression.由人类精神分裂症相关基因的同源物编码的分泌型免疫球蛋白A（SlgA）在生物钟神经元中发挥作用，以调节攻击性。
Dis Model Mech. 2017 Jun 1;10(6):705-716. doi: 10.1242/dmm.027151. Epub 2017 Mar 22.
6
The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design.CK2抑制剂的发展：从传统药理学到计算机辅助合理药物设计
Pharmaceuticals (Basel). 2017 Feb 20;10(1):26. doi: 10.3390/ph10010026.
7
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.在阿尔茨海默病病理学中，星形胶质细胞中蛋白激酶CK2的出现增加。
J Neuroinflammation. 2016 Jan 6;13:4. doi: 10.1186/s12974-015-0470-x.
8
Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.罕见的自闭症相关变异涉及 syntaxin 1（STX1 R26Q）磷酸化以及多巴胺转运体（hDAT R51W）在多巴胺神经传递和行为中的作用。
EBioMedicine. 2015 Feb;2(2):135-146. doi: 10.1016/j.ebiom.2015.01.007.
9
Casein kinase 2 phosphorylates GluA1 and regulates its surface expression.酪蛋白激酶2使谷氨酸受体1亚基（GluA1）磷酸化并调节其表面表达。
Eur J Neurosci. 2014 Apr;39(7):1148-58. doi: 10.1111/ejn.12494.
10
NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia.NMDA 功能低下是精神分裂症进展和症状的汇聚点。
Front Cell Neurosci. 2013 Mar 27;7:31. doi: 10.3389/fncel.2013.00031. eCollection 2013.