谷胱甘肽 S-转移酶 P1 和 alpha 基因变异；在口腔癌易感性和肿瘤大小发展中的作用。
Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.
出版信息
Head Neck. 2010 Aug;32(8):1079-87. doi: 10.1002/hed.21297.
BACKGROUND
The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.
METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.
RESULTS
Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.
CONCLUSIONS
The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer.
背景
本研究旨在评估谷胱甘肽 S-转移酶（GST）P1、GSTA1、GSTM1 和 GSTT1 基因多态性与口腔癌风险的关系。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测 274 例对照和 164 例口腔癌患者的这 4 种基因多态性。
结果
与野生型 A/A 纯合子相比，至少有 1 个 GSTP1 变异 G 等位基因的个体发生口腔癌的风险增加 1.53 倍（95%置信区间[CI]：1.01-2.31）。与 C/C 纯合子相比，至少有 1 个 GSTA1 基因变异 T 等位基因的口腔癌患者肿瘤大小>2cm 的风险降低 0.42 倍（95%CI：0.18-0.95）。
结论
GSTP1 的变异 G 等位基因可能被认为是增加易感性的因素，而 GSTA1 的 T 等位基因可能是台湾口腔癌患者肿瘤大小进展的保护因素。
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