Dong Gang, Tian Yan, Chen Shulan, Xu Xin, Zheng Jianjin, Li Tao
College of Stomatology, Key Lab of Oral Biomedicine of Shandong Province, Shandong University, 44-1 Wenhuaxi Road, Jinan, 250012, People's Republic of China.
Tumour Biol. 2013 Jun;34(3):1753-7. doi: 10.1007/s13277-013-0713-3. Epub 2013 Apr 23.
Though there are many studies assessing the association between glutathione S-transferase T1 (GSTT1) null genotype and oral cancer risk, the association between GSTT1 null genotype and oral cancer in Asian populations is still inconclusive. We performed a meta-analysis of 19 studies including 2,845 cases and 4,295 controls to derive a more precise estimation of the relationship. The pooled odds ratio (OR) with its corresponding 95 % confidence interval (95 % CI) was used to assess the relationship. Meta-analysis of those 19 studies suggested that there was an association between GSTT1 null genotype and elevated risk of oral cancer risk (OR = 1.25, 95 % CI = 1.00-1.56, P = 0.047). Sensitivity analysis by omitting one study at a time showed that the significance of the corresponding pooled ORs was materially altered frequently, indicating that the pooled ORs were not statistically stable. In addition, there was no obvious risk of publication bias in the meta-analysis. Therefore, the present meta-analysis suggests that the GSTT1 null genotype is a risk allele for oral cancer development in Asian populations, but more studies with large sample and well-matched controls are needed to further confirm the finding from the meta-analysis.
尽管有许多研究评估谷胱甘肽S-转移酶T1（GSTT1）缺失基因型与口腔癌风险之间的关联，但GSTT1缺失基因型与亚洲人群口腔癌之间的关联仍不明确。我们对19项研究进行了荟萃分析，包括2845例病例和4295例对照，以更精确地估计两者之间的关系。采用合并比值比（OR）及其相应的95%置信区间（95%CI）来评估这种关系。对这19项研究的荟萃分析表明，GSTT1缺失基因型与口腔癌风险升高之间存在关联（OR = 1.25，95%CI = 1.00 - 1.56，P = 0.047）。每次剔除一项研究进行敏感性分析表明，相应合并OR的显著性经常发生实质性改变，这表明合并OR在统计学上不稳定。此外，荟萃分析中没有明显的发表偏倚风险。因此，本荟萃分析表明，GSTT1缺失基因型是亚洲人群口腔癌发生的一个风险等位基因，但需要更多大样本且对照匹配良好的研究来进一步证实荟萃分析的结果。
