Seven different primary cancers in a single patient. A case report and review of multiple primary malignant neoplasia.

A 43-year-old female developed seven different primary carcinomas over a 14-year period. Six were adenocarcinomas and one a squamous carcinoma. Five of the six adenocarcinomas were locally advanced, but only two recurred after excision. There are very few reports in the literature of patients with seven or more primary cancers, but all demonstrated a remarkable absence of metastatic disease and surprisingly prolonged survival. They represent extreme examples of the phenomenon of multiple primary malignant neoplasia (MPMN) and the possibility of their belonging to a cancer family syndrome should always be considered.