Baigrie R J
Department of Cardio-Thoracic Surgery, John Radcliffe Hospital, Oxford.
Eur J Surg Oncol. 1991 Feb;17(1):81-3.
A 43-year-old female developed seven different primary carcinomas over a 14-year period. Six were adenocarcinomas and one a squamous carcinoma. Five of the six adenocarcinomas were locally advanced, but only two recurred after excision. There are very few reports in the literature of patients with seven or more primary cancers, but all demonstrated a remarkable absence of metastatic disease and surprisingly prolonged survival. They represent extreme examples of the phenomenon of multiple primary malignant neoplasia (MPMN) and the possibility of their belonging to a cancer family syndrome should always be considered.
一名43岁女性在14年期间患了7种不同的原发性癌。其中6种是腺癌，1种是鳞癌。6例腺癌中有5例为局部晚期，但切除后仅2例复发。文献中关于患有7种或更多原发性癌症患者的报道极少，但所有报道均显示明显无转移性疾病，且生存期出奇地延长。它们代表了多原发性恶性肿瘤（MPMN）现象的极端例子，应始终考虑其属于癌症家族综合征的可能性。
