Unity of Functional Proteomics and Food Biopreservation, Higher Institute of Applied Biological Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia.
Microbiol Immunol. 2009 Dec;53(12):658-66. doi: 10.1111/j.1348-0421.2009.00183.x.
Oudneya africana R. Br. (Brassicaceae), a wild-growing plant in the arid region of Tunisia, is used in ethno-medicinal treatment of microbial infections. Validation of ethno-therapeutic claims pertaining to the plant was sought by investigating its antimicrobial activity. A proteinaceous extract of the seeds, called AS-3000, showed activity against various organisms including L. monocytogenes, E. coli, B. subtilis, E. hirae, P. aeruginosa, S. aureus and C. albicans. Extract AS-3000 exhibited a synergistic effect against L. ivanovii when combined with vancomycin or chloramphenicol. The post-antibiotic inhibitory effect of the ampicillin/AS-3000 combination was 2.3-fold greater than for the antibiotic alone. The mode of action of AS-3000 on Listeria and Escherichia was visible using SEM. These results support the use of O. africana for treating microbial infections.
非洲油朴（十字花科）是突尼斯干旱地区的野生植物，在民间医学中用于治疗微生物感染。为了验证与该植物有关的民族治疗说法，研究了其抗菌活性。种子的一种蛋白质提取物，称为 AS-3000，对包括单核细胞增生李斯特菌、大肠杆菌、枯草芽孢杆菌、海氏肠球菌、铜绿假单胞菌、金黄色葡萄球菌和白色念珠菌在内的各种生物体表现出活性。当与万古霉素或氯霉素联合使用时，AS-3000 对伊万诺夫李斯特菌表现出协同作用。氨苄青霉素/AS-3000 联合用药的抗生素后抑制作用比单独使用抗生素强 2.3 倍。AS-3000 对李斯特菌和大肠杆菌的作用模式可以通过 SEM 观察到。这些结果支持使用非洲油朴治疗微生物感染。
