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Cell-mediated immune responses directed against hepatitis C virus (HCV) alternate reading frame protein (ARFP) are undetectable during acute infection.在急性感染期间，针对丙型肝炎病毒（HCV）替代阅读框蛋白（ARFP）的细胞介导免疫反应无法检测到。
J Clin Virol. 2010 Jan;47(1):102-3. doi: 10.1016/j.jcv.2009.10.016. Epub 2009 Dec 1.
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Memory T-cell-mediated immune responses specific to an alternative core protein in hepatitis C virus infection.丙型肝炎病毒感染中针对一种替代核心蛋白的记忆性T细胞介导的免疫反应。
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Recombinant expression of the alternate reading frame protein (ARFP) of hepatitis C virus genotype 4a (HCV-4a) and detection of ARFP and anti-ARFP antibodies in HCV-infected patients.丙型肝炎病毒4a型（HCV-4a）交替阅读框蛋白（ARFP）的重组表达及HCV感染患者中ARFP和抗ARFP抗体的检测
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The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others.丙型肝炎病毒替代阅读框（ARF）及其新型产物家族：替代阅读框蛋白/F蛋白、双移码蛋白等。
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Alternate reading frame protein (F protein) of hepatitis C virus: paradoxical effects of activation and apoptosis on human dendritic cells lead to stimulation of T cells.丙型肝炎病毒的读码框移码蛋白（F 蛋白）：活化和凋亡对人树突状细胞的矛盾作用导致 T 细胞的刺激。
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Sero-reactivity to three distinct regions within the hepatitis C virus alternative reading frame protein (ARFP/core+1) in patients with chronic HCV genotype-3 infection.慢性丙型肝炎病毒基因型 3 感染患者对丙型肝炎病毒替代读码框蛋白（ARFP/core+1）三个不同区域的血清反应性。
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Hepatitis C virus alternative reading frame protein (ARFP): Production, features, and pathogenesis.丙型肝炎病毒（HCV）的另类读码框蛋白（ARFP）：产生、特征和发病机制。
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Oral immunization with attenuated Salmonella carrying a co-expression plasmid encoding the core and E2 proteins of hepatitis C virus capable of inducing cellular immune responses and neutralizing antibodies in mice.口服免疫减毒沙门氏菌携带 co-expression 质粒，编码丙型肝炎病毒的核心和 E2 蛋白，能够在小鼠中诱导细胞免疫应答和中和抗体。
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Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission.母婴传播途径感染丙型肝炎病毒的儿童发生血清阴性肝炎。
J Clin Microbiol. 2012 Jul;50(7):2515-9. doi: 10.1128/JCM.00622-12. Epub 2012 Apr 25.
2
Characterization of the specific CD4+ T cell response against the F protein during chronic hepatitis C virus infection.慢性丙型肝炎病毒感染中针对 F 蛋白的特异性 CD4+ T 细胞应答的特征。
PLoS One. 2010 Dec 6;5(12):e14237. doi: 10.1371/journal.pone.0014237.
3
Adaptive immunity to the hepatitis C virus.对丙型肝炎病毒的适应性免疫。
Adv Virus Res. 2010;78:43-86. doi: 10.1016/B978-0-12-385032-4.00002-1.

本文引用的文献

1
Rare birds in North America: acute hepatitis C cohorts.北美珍稀鸟类：急性丙型肝炎队列研究
Gastroenterology. 2009 Jan;136(1):26-31. doi: 10.1053/j.gastro.2008.11.049. Epub 2008 Dec 4.
2
Immunogenicity of CIGB-230, a therapeutic DNA vaccine preparation, in HCV-chronically infected individuals in a Phase I clinical trial.治疗性DNA疫苗制剂CIGB-230在慢性丙型肝炎病毒感染个体中的I期临床试验免疫原性。
J Viral Hepat. 2009 Mar;16(3):156-67. doi: 10.1111/j.1365-2893.2008.01058.x. Epub 2008 Oct 31.
3
Subcellular localizations of the hepatitis C virus alternate reading frame proteins.丙型肝炎病毒可变读框蛋白的亚细胞定位
Virus Res. 2009 Jan;139(1):106-10. doi: 10.1016/j.virusres.2008.09.011. Epub 2008 Nov 28.
4
Ubiquitin-independent degradation of hepatitis C virus F protein.丙型肝炎病毒F蛋白的非泛素依赖性降解
J Virol. 2009 Jan;83(2):612-21. doi: 10.1128/JVI.00832-08. Epub 2008 Oct 29.
5
The major form of hepatitis C virus alternate reading frame protein is suppressed by core protein expression.丙型肝炎病毒可变阅读框蛋白的主要形式受到核心蛋白表达的抑制。
Nucleic Acids Res. 2008 May;36(9):3054-64. doi: 10.1093/nar/gkn111. Epub 2008 Apr 8.
6
Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc.丙型肝炎病毒ARFP/F蛋白与细胞MM-1蛋白相互作用，并增强c-Myc的基因反式激活活性。
J Biomed Sci. 2008 Jul;15(4):417-25. doi: 10.1007/s11373-008-9248-9. Epub 2008 Apr 9.
7
Development of specific antibodies to an ARF protein in treated patients with chronic HCV infection.慢性丙型肝炎病毒感染患者接受治疗后针对一种ARF蛋白的特异性抗体的产生。
Dig Dis Sci. 2007 Sep;52(9):2427-32. doi: 10.1007/s10620-006-9630-2. Epub 2007 Apr 10.
8
Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuries.丙型肝炎病毒可变阅读框蛋白的表达诱导参与肝损伤的细胞因子。
J Gen Virol. 2007 Apr;88(Pt 4):1149-1162. doi: 10.1099/vir.0.82575-0.
9
Evidence for a functional RNA element in the hepatitis C virus core gene.丙型肝炎病毒核心基因中功能性RNA元件的证据。
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2879-84. doi: 10.1073/pnas.0611267104. Epub 2007 Feb 13.
10
Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization.丙型肝炎病毒F蛋白与预折叠蛋白2相互作用会扰乱微管蛋白细胞骨架的组织。
Biochem Biophys Res Commun. 2006 Sep 15;348(1):271-7. doi: 10.1016/j.bbrc.2006.07.062. Epub 2006 Jul 24.

Cell-mediated immune responses directed against hepatitis C virus (HCV) alternate reading frame protein (ARFP) are undetectable during acute infection.

作者信息

Drouin Christian, Lamarche Stéphanie, Bruneau Julie, Soudeyns Hugo, Shoukry Naglaa H

出版信息

J Clin Virol. 2010 Jan;47(1):102-3. doi: 10.1016/j.jcv.2009.10.016. Epub 2009 Dec 1.

DOI:10.1016/j.jcv.2009.10.016
PMID:19955014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5094889/
Abstract
摘要