Department of Psychiatry and Psychotherapy, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, Dresden, Germany.
Arch Clin Neuropsychol. 2010 Feb;25(1):22-7. doi: 10.1093/arclin/acp098. Epub 2009 Dec 1.
Episodic autobiographical memory (ABM) is important for social functioning. Loss of specificity in ABM retrieval has been observed in people with mild to moderate Alzheimer's disease (AD). Our aim was to extend these findings to subjects with amnestic mild cognitive impairment (aMCI) and very early AD. We performed a cued ABM task with both subject groups and healthy elderly controls. Although aMCI participants performed better than early AD subjects both showed reduced specificity of ABM retrieval when compared with controls. We conclude that qualitative memory retrieval deficits could contribute to social functioning impairment in people with aMCI and early AD, and highlight the complexity of symptoms already present in early stages of cognitive impairment.
情景式自传体记忆(ABM)对社交功能很重要。在轻度至中度阿尔茨海默病(AD)患者中,已经观察到 ABM 检索的特异性丧失。我们的目的是将这些发现扩展到遗忘型轻度认知障碍(aMCI)和极早期 AD 患者。我们对这两个受试者组和健康的老年对照组进行了提示性 ABM 任务。尽管 aMCI 参与者的表现优于早期 AD 患者,但与对照组相比,他们的 ABM 检索特异性均降低。我们得出结论,定性记忆检索缺陷可能导致 aMCI 和早期 AD 患者的社交功能障碍,并强调认知障碍早期阶段已经存在的症状的复杂性。