Belfi C A, Medendorp S V, Ngo F Q
Laboratory of Radiobiology and NMR Research, Cleveland Clinic Foundation, OH 44195.
Int J Radiat Oncol Biol Phys. 1991 Mar;20(3):497-507. doi: 10.1016/0360-3016(91)90062-9.
The potential application of magnetic resonance imaging (MRI) to predict tumor response to radiotherapy is investigated. The water proton spin-lattice and spin-spin relaxation times (T2 and T2, respectively) of murine sarcomas (designated KHT) were measured shortly after excision. This study has demonstrated significantly different responses in T1 and T2 between the control and the irradiated tumors at various times following single doses of X rays. Quite generally, the changes in relaxation times correlated with the changes in tumor water content, indicating that the MR relaxation-time probes are fairly sensitive to radiation-induced edema and dehydration. The possible relationships between the T1 and T2 responses and radiobiological effects such as those on tumor blood flow, vascular permeability, physiological state of cells, and cell death are discussed. It is conceivable that the findings obtained from this investigation could be extended to in situ studies for potential applications in clinical radiotherapy.
研究了磁共振成像（MRI）预测肿瘤对放疗反应的潜在应用。在切除小鼠肉瘤（命名为KHT）后不久，测量了其水质子自旋 - 晶格和自旋 - 自旋弛豫时间（分别为T1和T2）。本研究表明，单次X射线照射后不同时间，对照肿瘤和照射肿瘤的T1和T2反应存在显著差异。一般来说，弛豫时间的变化与肿瘤含水量的变化相关，这表明磁共振弛豫时间探针对辐射诱导的水肿和脱水相当敏感。讨论了T1和T2反应与放射生物学效应（如对肿瘤血流、血管通透性、细胞生理状态和细胞死亡的影响）之间的可能关系。可以想象，从这项研究中获得的结果可以扩展到原位研究，以便在临床放疗中潜在应用。
