Laboratory of Dermatopathology, Edouard Herriot Hospital, Lyon, France.
Dermatology. 2010;220(2):143-6. doi: 10.1159/000264607. Epub 2009 Dec 2.
Circumscribed palmoplantar hypokeratosis (CPH) is a recently described dermatosis of unknown origin, of which 46 cases have been published so far. CPH affects predominantly adult women. It presents clinically with a sharply circumscribed annular erythematous depressed plaque rimmed by a slightly hyperkeratotic border, localized usually over the thenar or hypothenar eminences of the palm, less commonly on the soles. Histopathologically, it is characterized by an abrupt decrease in the horny layer thickness, forming a sharp stair between normal and involved skin. We report herein a new patient with CPH who presented an associated aspect of actinic keratosis, a hitherto unreported finding. This case suggests that CPH can undergo malignant transformation, probably as a result of actinic damage. On this occasion, a complete literature review of CPH is presented.
局限性掌跖角化病（CPH）是一种新近描述的病因不明的皮肤病，迄今为止已发表了 46 例病例。CPH 主要影响成年女性。临床上表现为界限清楚的环形红斑性凹陷性斑块，边缘稍角化过度，通常位于手掌的大鱼际或小鱼际隆起处，较少见于足底。组织病理学上，其特征是角质层厚度突然减少，在正常和受累皮肤之间形成明显的阶梯状。我们在此报告一例新的局限性掌跖角化病患者，其表现为光化性角化病的相关表现，这是一种迄今未报道的发现。该病例提示 CPH 可能发生恶性转化，可能是由于光损伤所致。在此情况下，我们对 CPH 的完整文献进行了回顾。
