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本文引用的文献

1
Premalignant circumscribed palmar hypokeratosis: a new form of circumscribed palmar hypokeratosis? Case report and literature review.局限性掌跖角化不足症恶变前期：局限性掌跖角化不足症的一种新形式？病例报告及文献复习。
Dermatology. 2010;220(2):143-6. doi: 10.1159/000264607. Epub 2009 Dec 2.
2
Circumscribed palmo-plantar hypokeratosis: a disease with two subtypes.局限性掌跖角化不全症：一种有两种亚型的疾病。
J Invest Dermatol. 2009 Apr;129(4):1045-7. doi: 10.1038/jid.2008.306. Epub 2008 Sep 25.
3
Circumscribed palmar hypokeratosis: two cases and a review of the literature.
J Cutan Pathol. 2008 May;35(5):484-7. doi: 10.1111/j.1600-0560.2007.00835.x.
4
Circumscribed palmar hypokeratosis: partial remission by photodynamic therapy.局限性掌部角化不全：光动力疗法部分缓解
Br J Dermatol. 2007 Oct;157(4):804-6. doi: 10.1111/j.1365-2133.2007.08053.x. Epub 2007 Jun 26.
5
Abnormal keratin expression in circumscribed palmar hypokeratosis.局限性掌部角化不全中的异常角蛋白表达。
J Am Acad Dermatol. 2007 Aug;57(2):285-91. doi: 10.1016/j.jaad.2007.02.035. Epub 2007 Jun 5.
6
Circumscribed acral hypokeratosis.局限性肢端角化减退症
J Am Acad Dermatol. 2007 Aug;57(2):292-6. doi: 10.1016/j.jaad.2007.02.022. Epub 2007 Apr 6.
7
Circumscribed palmar hypokeratosis: successful treatment with cryotherapy.局限性手掌角化不全：冷冻疗法治疗成功
J Eur Acad Dermatol Venereol. 2007 Mar;21(3):420-1. doi: 10.1111/j.1468-3083.2006.01908.x.
8
Circumscribed palmar hypokeratosis: new observations.
Am J Dermatopathol. 2006 Apr;28(2):112-6. doi: 10.1097/01.dad.0000193825.90552.4e.
9
Circumscribed palmar hypokeratosis: clinical evolution and ultrastructural study after prolonged treatment with topical calcipotriol.局限性掌部角化减退症：外用卡泊三醇长期治疗后的临床演变及超微结构研究
J Eur Acad Dermatol Venereol. 2005 Jul;19(4):491-4. doi: 10.1111/j.1468-3083.2005.01197.x.
10
Circumscribed palmar or plantar hypokeratosis: two cases of a recently described entity of unknown origin.
Am J Dermatopathol. 2005 Jun;27(3):247-9. doi: 10.1097/01.dad.0000141973.23896.ca.

局限性掌跖角化过度症：氟尿嘧啶乳膏治疗成功。

Circumscribed palmar hypokeratosis: Successful treatment with fluorouracil cream.

机构信息

Dermatohistological Laboratory and Private Practice, Postfach 4145, 90021 Nuernberg, Germany.

出版信息

Dermatol Ther (Heidelb). 2011 Sep;1(1):11-4. doi: 10.1007/s13555-011-0002-2. Epub 2011 May 4.

DOI:10.1007/s13555-011-0002-2
PMID:22984658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3437638/
Abstract

INTRODUCTION

The pathogenesis of circumscribed palmar hypokeratosis (CPH) is still controversial, and to date there is no treatment of choice.

METHODS

We report on a patient with CPH responding to treatment with fluorouracil cream.

RESULTS

The clinical course and histopathological features in our observation point towards the possibility of an underlying squamous cell carcinoma in situ presenting as CPH.

CONCLUSION

We suggest that fluorouracil cream treatment should be considered as a therapeutic option in cases of CPH.

摘要

简介

局限性掌跖角化病（CPH）的发病机制仍存在争议，迄今为止尚无首选治疗方法。

方法

我们报告了一例 CPH 患者对氟尿嘧啶乳膏治疗有反应的病例。

结果

我们的观察结果提示，CPH 可能存在潜在的鳞状细胞原位癌。

结论

我们建议氟尿嘧啶乳膏治疗应作为 CPH 的一种治疗选择。