Department of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Tallinn, Estonia.
Blood Purif. 2010;29(1):69-74. doi: 10.1159/000264269. Epub 2009 Dec 3.
This study estimates the total removal of uric acid (TR(UA)) by online UV absorbance measurements in the spent dialysate in two different dialysis centers in Estonia and Sweden. Sixteen dialysis patients were included. All dialysate was collected that gave the reference for TR(UA). Two regression models were investigated: one for each patient (UV1) and one for the entire material (UV2). TR(UA) from the three methods was in the same order but showed a statistically significant difference when the UV2 model was built on data from both centers together. TR(UA), (n = 56) was (mean +/- SD, micromol): 5,854 +/- 1,377 for reference, 6,117 +/- 1,795 for UV1 and 5,762 +/- 1,591 for UV2. Six patients were monitored 1 year after the first study session, using the same models as the previous year, still having a nonsignificant difference. The results show the possibility of estimating TR(UA) by using UV absorbance. The method appeared to be reliable also in long-term patient monitoring.
本研究旨在估算爱沙尼亚和瑞典两个不同透析中心中在线紫外线吸光度测量法在消耗性透析液中对尿酸（UA）总清除率（TR(UA)）的影响。共纳入 16 名透析患者。收集所有用于参考的透析液。研究了两种回归模型：一种是针对每个患者（UV1），另一种是针对整个材料（UV2）。三种方法的 TR(UA)结果顺序相同，但当将 UV2 模型建立在两个中心的数据上时，存在统计学上的显著差异。TR(UA)（n = 56）的参考值为（平均值 +/- 标准差，微摩尔）：5,854 +/- 1,377；UV1 为 6,117 +/- 1,795；UV2 为 5,762 +/- 1,591。6 名患者在第一年的研究后，使用与前一年相同的模型进行了为期一年的监测，差异仍无统计学意义。结果表明，通过紫外线吸光度估计 TR(UA)是可行的。该方法在长期患者监测中也显示出可靠性。
