Department of Oncology, Institute of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Chemotherapy. 2009;55(6):407-13. doi: 10.1159/000263227. Epub 2009 Dec 2.
FXYD3 is up-/down-regulated in different types of cancers. We examined FXYD3 expression in colorectal cancers and its relationship to biological and clinicopathological variables.
Expression of FXYD3 protein was immunohistochemically examined in distant normal mucosa (n = 34), adjacent normal mucosa (n = 72), primary tumour (n = 150) and lymph node metastasis (n = 35) from colorectal cancer patients.
FXYD3 was highly expressed in primary tumour compared to adjacent normal mucosa (p = 0.02). FXYD3 was or tended to be positively related to the expression of ras (p = 0.02), p53 (p = 0.06), legumain (p = 0.02) and proliferating cell nuclear antigen (p = 0.03). Moreover, there was a higher frequency of strong FXYD3 expression in Dukes A-C tumours than in D tumours (p = 0.04). The strong FXYD3 expression tended to predict worse survival in the patients with Dukes A + B tumour (p = 0.07), while there was no such tendency in the patients with Dukes C + D tumour (p = 0.94). The tumours located in the colon had a higher degree of FXYD3 expression than the tumours located in the rectum (p = 0.05).
The FXYD3 was associated with certain biological variables and may be involved in the development of the relative earlier stages of colorectal cancers.
FXYD3 在不同类型的癌症中上调/下调。我们检查了结直肠癌中的 FXYD3 表达及其与生物学和临床病理变量的关系。
用免疫组织化学法检测来自结直肠癌患者的远处正常粘膜（n = 34）、相邻正常粘膜（n = 72）、原发肿瘤（n = 150）和淋巴结转移（n = 35）中 FXYD3 蛋白的表达。
FXYD3 在原发肿瘤中的表达明显高于相邻正常粘膜（p = 0.02）。FXYD3 的表达与 ras（p = 0.02）、p53（p = 0.06）、legumain（p = 0.02）和增殖细胞核抗原（p = 0.03）的表达呈正相关或倾向于正相关。此外，Dukes A-C 期肿瘤中强 FXYD3 表达的频率高于 D 期肿瘤（p = 0.04）。强 FXYD3 表达倾向于预测 Dukes A + B 期肿瘤患者的生存不良（p = 0.07），而 Dukes C + D 期肿瘤患者则无此趋势（p = 0.94）。位于结肠的肿瘤的 FXYD3 表达程度高于位于直肠的肿瘤（p = 0.05）。
FXYD3 与某些生物学变量相关，可能参与了结直肠癌相对早期阶段的发展。
