Palazzoli Fabien, Testu François-Xavier, Merly Franck, Bigot Yves
UFR des Sciences & Techniques, Université François Rabelais de Tours, GICC, Tours, France.
Genetica. 2010 Mar;138(3):285-99. doi: 10.1007/s10709-009-9426-3. Epub 2009 Dec 3.
DNA transposons are considered to be good candidates for developing tools for genome engineering, insertional mutagenesis and gene delivery for therapeutic purposes, as illustrated by the recent first clinical trial of a transposon. In this article we set out to highlight the interest of patent information, and to develop a strategy for the technological development of transposon tools, similar to what has been done in many other fields. We propose a patent landscape for transposon tools, including the changes in international patent applications, and review the leading inventors and applicants. We also provide an overview of the potential patent portfolio for the prokaryotic and eukaryotic transposons that are exploited by spin-off companies. Finally, we discuss the difficulties involved in tracing relevant state-of-the-art of articles and patent documents, based on the example of one of the most promising transposon systems, including all the impacts on the technological development of transposon tools.
DNA转座子被认为是开发用于基因组工程、插入诱变和治疗性基因传递工具的理想候选者，最近一项转座子的首次临床试验就证明了这一点。在本文中，我们旨在突出专利信息的重要性，并制定一种转座子工具技术开发策略，类似于许多其他领域所采用的方法。我们提出了转座子工具的专利格局，包括国际专利申请的变化，并回顾了主要的发明人和申请人。我们还概述了衍生公司所利用的原核和真核转座子的潜在专利组合。最后，我们以最有前景的转座子系统之一为例，讨论追踪相关文章和专利文献现有技术的困难，以及这对转座子工具技术开发的所有影响。
