Department of Biomaterials/Handicap Research, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
J Biomed Mater Res B Appl Biomater. 2010 Feb;92(2):462-9. doi: 10.1002/jbm.b.31538.
Lately, there has been a growing interest in how the presence of nanometer structures on a bone integrated implant surface influences the healing process. Recent in vitro studies have revealed an increased osteoblast response to different nanophase surfaces. Some commercial implant brands claim their implants have nanometer structures. However, at present, there are no studies where the nano topography of today's commercially available oral implants has been investigated. The aim of this study was to characterize commercial oral implants on the nanometer level and to investigate whether or not the nanometer surface roughness was correlated to the more well-known micrometer roughness on the implants. Twelve different commercial screw-shaped oral implants with various surface modifications were examined using scanning electron microscopy and a white light interferometer. The interferometer is suitable for detection of nanoscale roughness in the vertical dimension; however, limitation exists on the horizontal due to the wavelength of the light. A 1 x 1 microm Gaussian filter was found to be useful for identifying nm roughness with respect to height deviation. The results demonstrated that an implant that was smooth on the micrometer level was not necessarily smooth on the nanometer level. Different structures in the nanometer scale was found on some of the implants, indicating that to fully understand the relationship between the properties of an implant surface and its osseointegration behavior, a characterization at the nanometer scale might be relevant.
最近，人们越来越关注骨整合植入物表面纳米结构的存在如何影响愈合过程。最近的体外研究表明，不同的纳米相表面会引起成骨细胞反应增强。一些商业植入物品牌声称其植入物具有纳米结构。然而，目前还没有研究调查当今市售口腔植入物的纳米形貌。本研究的目的是在纳米尺度上对商业口腔植入物进行特征描述，并研究纳米表面粗糙度是否与植入物上更为人熟知的微米粗糙度相关。使用扫描电子显微镜和白光干涉仪检查了 12 种不同的具有各种表面改性的商用螺钉状口腔植入物。干涉仪适用于检测垂直方向上的纳米级粗糙度；然而，由于光的波长，在水平方向上存在限制。发现 1 x 1 微米高斯滤波器对于确定相对于高度偏差的 nm 粗糙度很有用。结果表明，在微米水平上光滑的植入物在纳米水平上不一定光滑。一些植入物上发现了纳米级的不同结构，这表明为了充分了解植入物表面特性与其骨整合行为之间的关系，在纳米尺度上进行特征描述可能是相关的。
