碱改性 NANOZR 种植体的骨整合：一项体内研究。
Osseointegration of Alkali-Modified NANOZR Implants: An In Vivo Study.
机构信息
Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 8-1, Kuzuhahanazono-cho, Hirakata-shi, Osaka 5731121, Japan.
Osaka Research Institute of Industrial Science and Technology Morinomiya Center, 1-6-50, Morinomiya, Joto-ku, Osaka-shi 5368553, Japan.
出版信息
Int J Mol Sci. 2019 Feb 15;20(4):842. doi: 10.3390/ijms20040842.
Ingredients and surface modification methods are being continually developed to improve osseointegration of dental implants and reduce healing times. In this study, we demonstrate in vitro that, by applying concentrated alkali treatment to NANOZR with strong bending strength and fracture toughness, a significant improvement in the bone differentiation of rat bone marrow cells can be achieved. We investigated the influence of materials modified with this treatment in vivo, on implanted surrounding tissues using polychrome sequential fluorescent labeling and micro-computer tomography scanning. NANOZR implant screws in the alkali-treated group and the untreated group were evaluated after implantation in the femur of Sprague⁻Dawley male rats, indicating that the amount of new bone in the alkali-modified NANOZR was higher than that of unmodified NANOZR. Alkali-modified NANOZR implants proved to be useful for the creation of new implant materials.
成分和表面改性方法正在不断发展，以提高牙科植入物的骨整合和减少愈合时间。在这项研究中，我们通过体外实验证明，通过对具有高强度弯曲强度和断裂韧性的 NANOZR 进行浓碱处理，可以显著提高大鼠骨髓细胞的骨分化。我们通过多色顺序荧光标记和微计算机断层扫描研究了这种处理方法对植入物周围组织的体内影响。在 Sprague-Dawley 雄性大鼠的股骨中植入 NANOZR 种植螺钉后，评估了碱处理组和未处理组的 NANOZR 种植螺钉，结果表明，经过碱处理的 NANOZR 的新生骨量高于未经处理的 NANOZR。经过碱处理的 NANOZR 植入物被证明是一种有用的新型植入材料。
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