Gao Yaojun, Lam Yulin
Department of Chemistry, National University of Singapore, Singapore.
J Comb Chem. 2010 Jan-Feb;12(1):69-74. doi: 10.1021/cc900063y.
A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles to the pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones which provided the compounds in good yields was demonstrated. Using this synthetic strategy, we prepared a representative set of 16 pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones.
已开发出5-氨基吡唑的固相合成方法，并将其应用于吡唑并[5,1-d][1,2,3,5]四嗪-4(3H)-酮的制备。在该策略中，展示了从5-氨基吡唑到吡唑并[5,1-d][1,2,3,5]四嗪-4(3H)-酮的一锅法反应，该反应能以良好的产率提供这些化合物。使用这种合成策略，我们制备了一组具有代表性的16种吡唑并[5,1-d][1,2,3,5]四嗪-4(3H)-酮。
