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5-氨基吡唑的合成方法。

Approaches towards the synthesis of 5-aminopyrazoles.

机构信息

Department of Chemistry, Kurukshetra University, Kurukshetra-136 119, Haryana, India.

出版信息

Beilstein J Org Chem. 2011 Feb 9;7:179-97. doi: 10.3762/bjoc.7.25.

DOI:10.3762/bjoc.7.25
PMID:21448263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3063075/
Abstract

The biological and medicinal properties of 5-aminopyrazoles have prompted enormous research aimed at developing synthetic routes to these heterocyles. This review focuses on the biological properties associated with this system. Various synthetic methods developed up to 2010 for these compounds are described, particularly those that involve the reactions of β-ketonitriles, malononitrile, alkylidenemalononitriles and their derivatives with hydrazines, as well as some novel miscellaneous methods.

摘要

5-氨基吡唑的生物和药用特性促使人们进行了大量的研究，旨在开发合成这些杂环的途径。本文重点介绍与该体系相关的生物特性。描述了截至 2010 年为这些化合物开发的各种合成方法，特别是涉及β-酮腈、丙二腈、亚甲基丙二腈及其衍生物与肼的反应，以及一些新颖的杂项方法。

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