Division of Otolaryngology, University of British Columbia, Vancouver, British Columbia.
J Otolaryngol Head Neck Surg. 2009 Dec;38(6):624-7.
We present the largest case series on laryngeal candidiasis and review the literature on the diagnosis and management of laryngeal candidiasis.
Fifty-four patients were included in a retrospective chart review of all cases seen at the Pacific Voice Clinic, University of British Columbia, Vancouver, from 1995 to 2005.
The most common presenting symptom was dysphonia (37 patients; 69%). Forty-eight patients (89%) were on steroid inhalers, and four patients (7%) were on oral prednisone. In terms of anatomic involvement, 18 patients (33%) showed Candida involvement in all three anatomic locations: the hypopharynx, the supraglottis, and the glottis. In 15 patients (28%), the Candida was isolated to the glottis. The remaining patients showed subglottic and glottic involvement. Fifty-two patients (96%) were successfully treated with a single course of an oral antifungal.
The most common risk factor identified was inhaled steroids. Most often, laryngeal candidiasis is effectively treated with oral antifungal medications.
我们呈现了最大的关于喉念珠菌病的病例系列，并回顾了有关喉念珠菌病的诊断和治疗的文献。
对 1995 年至 2005 年在不列颠哥伦比亚大学温哥华太平洋语音诊所就诊的所有病例进行回顾性图表审查，共纳入 54 例患者。
最常见的首发症状是声音嘶哑（37 例；69%）。48 例患者（89%）正在使用吸入性类固醇，4 例患者（7%）正在口服泼尼松。在解剖学受累方面，18 例患者（33%）的喉咽部、声门上区和声带均存在念珠菌感染。15 例患者（28%）的念珠菌仅局限于声带。其余患者表现为声门下和声带受累。52 例患者（96%）经单次口服抗真菌治疗后成功治愈。
确定的最常见危险因素是吸入性类固醇。大多数情况下，喉念珠菌病经口服抗真菌药物有效治疗。
