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1-[(氨基烷基)氨基]-4-羟基-10-亚氨基-9-蒽酮的合成、过氧化能力及抗肿瘤评估

Synthesis, peroxidating ability, and antineoplastic evaluation of 1-[(aminoalkyl)amino]-4-hydroxy-10-imino-9-anthracenones.

作者信息

Dzieduszycka M, Martelli S, Tarasiuk J, Paradziej-Lukowicz J, Borowski E

机构信息

Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.

出版信息

J Med Chem. 1991 Feb;34(2):541-6. doi: 10.1021/jm00106a009.

DOI:10.1021/jm00106a009
PMID:1995874
Abstract

A novel group of cytotoxic anthraquinone derivatives, 1-[(aminoalkyl)amino]-4-hydroxy-10-imino-9-anthracenones, has been synthesized. It has been shown that imino analogues of the anthracenediones exhibit diminished ability to generate oxygen radicals. The cytotoxic activity of iminoanthracenones obtained was lower than that of the related quinone carbonyl analogues. One of the obtained imino compounds showed a moderate antileukemic activity in vivo.

摘要

合成了一组新型的细胞毒性蒽醌衍生物，即1-[(氨基烷基)氨基]-4-羟基-10-亚氨基-9-蒽酮。已表明蒽二酮的亚氨基类似物产生氧自由基的能力减弱。所得到的亚氨基蒽醌的细胞毒性活性低于相关的醌羰基类似物。所得到的一种亚氨基化合物在体内表现出中等的抗白血病活性。

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