不对称取代的1,4-双[(氨基烷基)氨基]蒽-9,10-二酮作为潜在抗白血病药物的合成。
Synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones as potential antileukemic agents.
作者信息
Stefanska B, Dzieduszycka M, Martelli S, Borowski E
机构信息
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
出版信息
J Med Chem. 1989 Aug;32(8):1724-8. doi: 10.1021/jm00128a009.
PMID:2754697
Abstract
The synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones bearing one "mitoxantrone side arm" and another (aminoalkyl)amino moiety has been described. These unsymmetrical anthracene-9,10-diones exhibit cytotoxic activity against L1210 leukemia cells and antitumor activity against P388 leukemia in mice.
摘要
已报道了带有一个“米托蒽醌侧链”和另一个（氨基烷基）氨基部分的不对称取代的1,4 - 双[（氨基烷基）氨基]蒽醌 - 9,10 - 二酮的合成。这些不对称蒽醌 - 9,10 - 二酮对L1210白血病细胞表现出细胞毒性活性，并对小鼠的P388白血病表现出抗肿瘤活性。
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