杂取代蒽-9,10-二酮类似物。5,8-双[（氨基烷基）氨基]萘并[2,3-b]噻吩-4,9-二酮的合成与抗肿瘤评价。
Heterosubstituted anthracene-9,10-dione analogues. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b] thiophene-4,9-diones.
作者信息
Krapcho A P, Petry M E, Hacker M P
机构信息
Department of Chemistry, University of Vermont, Burlington 05405.
出版信息
J Med Chem. 1990 Sep;33(9):2651-5. doi: 10.1021/jm00171a048.
PMID:2391703
Abstract
A number of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4, 9-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Two of the congeners exhibited in vivo activities quite comparable to that of mitoxantrone.
摘要
已经合成了多种5,8-双[（氨基烷基）氨基]萘并[2,3 - b]噻吩-4,9 - 二酮，并对其进行了体外和体内抗L1210白血病的抗肿瘤活性评估。其中两种同系物在体内的活性与米托蒽醌相当。
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