5,8-双[(氨基烷基)氨基]-1-氮杂蒽-9,10-二酮的合成与抗肿瘤活性评价
Synthesis and antineoplastic evaluations of 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones.
作者信息
Krapcho A P, Landi J J, Hacker M P, McCormack J J
出版信息
J Med Chem. 1985 Aug;28(8):1124-6. doi: 10.1021/jm00146a029.
PMID:4020835
Abstract
Several 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Comparisons are made to the corresponding carbocyclic analogues. One of the aza analogues showed modest in vivo activity.
摘要
已合成了几种5,8-双[（氨基烷基）氨基]-1-氮杂蒽-9,10-二酮，并对其在体外和体内针对L1210白血病的抗肿瘤活性进行了评估。将其与相应的碳环类似物进行了比较。其中一种氮杂类似物显示出适度的体内活性。
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