Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Am Heart J. 2009 Dec;158(6):1031-7. doi: 10.1016/j.ahj.2009.10.003.
Peak oxygen uptake (Vo(2peak)) strongly predicts mortality in cardiac patients. We compared the effects of aerobic interval training (AIT) versus moderate continuous training (MCT) on Vo(2peak) and quality of life after coronary artery bypass grafting (CABG).
Fifty-nine CABG patients were randomized to either AIT at 90% of maximum heart rate or MCT at 70% of maximum heart rate, 5 d/wk, for 4 weeks at a rehabilitation center. Primary outcome was Vo(2peak), at baseline, after rehabilitation (4 weeks), and after 6 months of home-based exercise (6 months).
Vo(2peak) increased between baseline and 4 weeks in AIT (27.1 +/- 4.5 vs 30.4 +/- 5.5 mL.kg(-1).min(-1), P < .001) and MCT (26.2 +/- 5.2 vs 28.5 +/- 5.6 mL.kg(-1).min(-1), P < .001; group difference, not significant). Aerobic interval training increased Vo(2peak) between 4 weeks and 6 months (30.4 +/- 5.5 vs 32.2 +/- 7.0 mL.kg(-1).min(-1), P < .001), with no significant change in MCT (28.5 +/- 5.6 vs 29.5 +/- 5.7 mL.kg(-1).min(-1)). Quality of life improved in both groups from baseline to 4 weeks, remaining improved at 6 months. There were no changes in echocardiographic systolic and diastolic left ventricular function. Adiponectin increased between 4 weeks and 6 months in both groups (group differences, not significant).
Four weeks of intense training increased Vo(2peak) significantly after both AIT and MCT. Six months later, the AIT group had a significantly higher Vo(2peak) than MCT. The results indicate that AIT and MCT increase Vo(2peak) similarly in the short term, but with better long-term effect of AIT after CABG.
最大摄氧量（Vo(2peak)）强烈预测心脏患者的死亡率。我们比较了有氧间隔训练（AIT）与中等持续训练（MCT）对冠状动脉旁路移植术后（CABG）Vo(2peak)和生活质量的影响。
59 名 CABG 患者随机分为 AIT 组（最大心率的 90%）或 MCT 组（最大心率的 70%），每周 5 天，在康复中心进行 4 周的训练。主要结局为基线、康复后（4 周）和家庭运动后 6 个月（6 个月）的 Vo(2peak)。
AIT 组的 Vo(2peak)在基线和 4 周之间增加（27.1 +/- 4.5 对 30.4 +/- 5.5 mL.kg(-1).min(-1)，P <.001）和 MCT 组（26.2 +/- 5.2 对 28.5 +/- 5.6 mL.kg(-1).min(-1)，P <.001；组间差异无统计学意义）。AIT 在 4 周和 6 个月之间增加了 Vo(2peak)（30.4 +/- 5.5 对 32.2 +/- 7.0 mL.kg(-1).min(-1)，P <.001），而 MCT 没有显著变化（28.5 +/- 5.6 对 29.5 +/- 5.7 mL.kg(-1).min(-1)）。两组患者的生活质量均从基线到 4 周有所改善，6 个月时仍保持改善。两组患者的超声心动图收缩和舒张左心室功能均无变化。脂联素在两组中均在 4 周和 6 个月之间增加（组间差异无统计学意义）。
4 周的强化训练显著增加了 AIT 和 MCT 后 Vo(2peak)。6 个月后，AIT 组的 Vo(2peak)明显高于 MCT 组。结果表明，AIT 和 MCT 在短期内均可增加 Vo(2peak)，但 CABG 后 AIT 的长期效果更好。
