Obstructive Lung Disease In Northern Sweden Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Luleå, Sweden.
J Clin Epidemiol. 2010 Jul;63(7):783-9. doi: 10.1016/j.jclinepi.2009.08.017. Epub 2009 Dec 2.
To study whether the methodological change from parent to index subject as questionnaire respondent affected the prevalence estimates and risk factor patterns for allergic diseases in a longitudinal study.
A prospective study of asthma and allergic diseases among children was begun in 1996 within the Obstructive Lung Disease in Northern Sweden Study. In 2002, about 3,342 (95% of invited) teenagers (13 to 14 years) completed the annual questionnaire. A random sample of 294 (84% of invited) parents also completed the same extended International Study of Asthma and Allergies in Childhood questionnaire. Skin prick tests were performed in 1996 and 2000.
There were no significant differences in the prevalence of rhinitis, eczema, or related environmental factors between parental and self-reports, except for the question of having a dog at home. The absolute agreement was high, whereas the kappa values were fair or moderate. Kappa values of questions regarding parental smoking were 0.8-0.9. Allergic sensitization was the major risk factor for both rhinitis and eczema, and the odds ratios were similar regardless of who reported the condition.
The agreement between the parental and teenagers' reports was good, and the methodological change did not affect the study results.
研究在纵向研究中,将问卷调查的应答者由父母更改为子女索引个体,是否会影响过敏疾病的患病率估计和危险因素模式。
1996 年,在瑞典北部阻塞性肺病研究中开始了一项儿童哮喘和过敏疾病的前瞻性研究。2002 年,约有 3342 名(受邀者的 95%)青少年(13 至 14 岁)完成了年度问卷调查。随机抽取的 294 名(受邀者的 84%)父母也完成了相同的扩展国际儿童哮喘和过敏研究问卷调查。1996 年和 2000 年进行了皮肤点刺试验。
除了家中是否有狗的问题外,父母报告和自我报告的鼻炎、湿疹或相关环境因素的患病率没有显著差异。绝对一致性很高,而kappa 值为适度或中度。关于父母吸烟的问题的 kappa 值为 0.8-0.9。过敏致敏是鼻炎和湿疹的主要危险因素,并且无论谁报告该情况,其比值比都相似。
父母和青少年报告之间的一致性良好,方法学的改变并未影响研究结果。