Department of Medicine, Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA.
Nat Rev Immunol. 2010 Jan;10(1):36-46. doi: 10.1038/nri2675. Epub 2009 Dec 4.
A key event in atherosclerosis is a maladaptive inflammatory response to subendothelial lipoproteins. A crucial aspect of this response is a failure to resolve inflammation, which normally involves the suppression of inflammatory cell influx, effective clearance of apoptotic cells and promotion of inflammatory cell egress. Defects in these processes promote the progression of atherosclerotic lesions into dangerous plaques, which can trigger atherothrombotic vascular disease, the leading cause of death in industrialized societies. In this Review I provide an overview of these concepts, with a focus on macrophage death and defective apoptotic cell clearance, and discuss new therapeutic strategies designed to boost inflammation resolution in atherosclerosis.
动脉粥样硬化的一个关键事件是对血管内皮下脂蛋白的适应性炎症反应。这种反应的一个关键方面是炎症无法解决，这通常涉及抑制炎症细胞的流入、有效清除凋亡细胞和促进炎症细胞的流出。这些过程的缺陷会促进动脉粥样硬化病变向危险斑块的进展，从而引发动脉粥样硬化血栓形成性血管疾病，这是工业化社会中死亡的主要原因。在这篇综述中，我概述了这些概念，重点讨论了巨噬细胞死亡和凋亡细胞清除缺陷，并讨论了旨在增强动脉粥样硬化炎症解决的新治疗策略。
