Feudjo-Tepie M A, Le Roux G, Beach K J, Bennett D, Robinson N J
Worldwide Epidemiology, GlaxoSmithKline R & D, Greenford, Middlesex, UB6 0HE, UK.
Adv Hematol. 2009;2009:963506. doi: 10.1155/2009/963506. Epub 2009 Apr 2.
A person experiencing more than one medical condition may have ambiguous clinical presentation. ITP is a serious autoimmune disease with little epidemiological evidence on its burden, risk factors, and comorbidities. Using the United Kingdom general practice research database, we conducted a 14 years population-based case control-type study to explore medical conditions more likely to cooccur with ITP and their temporal relationship in association with ITP. ITP patients were matched to non-ITP on practice, age, gender, and follow-up period. Potential comorbidities were represented by patients' medical information at the preferred term level of the MedDRA international classification. As well as death (OR = 60.0; 95% CI [4.47-806.0]) and known clinical signs and symptoms of ITP, ITP is associated with considerable number of medical conditions. The association between ITP and some of these conditions is apparent both before and after ITP diagnosis. Specific targeted studies can now be setup to reexamine observed associations.
患有多种疾病的人可能有不明确的临床表现。免疫性血小板减少症（ITP）是一种严重的自身免疫性疾病，关于其负担、风险因素和合并症的流行病学证据很少。利用英国全科医疗研究数据库，我们进行了一项为期14年的基于人群的病例对照研究，以探讨更可能与ITP同时出现的疾病及其与ITP相关的时间关系。ITP患者在医疗机构、年龄、性别和随访期方面与非ITP患者进行匹配。潜在的合并症由患者在国际医学用语词典（MedDRA）国际分类的首选术语级别上的医疗信息表示。除了死亡（比值比=60.0；95%置信区间[4.47-806.0]）以及ITP已知的临床体征和症状外，ITP还与相当数量的疾病相关。ITP与其中一些疾病之间的关联在ITP诊断之前和之后都很明显。现在可以开展特定的针对性研究来重新审视观察到的关联。
