Mansour Khaled, Taher Ali T, Musallam Khaled M, Alam Samir
Division of Cardiology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
Adv Hematol. 2009;2009:937352. doi: 10.1155/2009/937352. Epub 2009 Apr 14.
The development of adverse cardiovascular events despite aspirin use has established an interest in a possible resistance to the drug. Several definitions have been set and various laboratory testing modalities are available. This has led to a wide range of prevalence reports in different clinical entities. The etiologic mechanism has been related to clinical, genetic, and other miscellaneous factors. The clinical implications of this phenomenon are significant and warrant concern. Management strategies are currently limited to dosing alteration and introduction of other anitplatelet agents. However, these measures have not met the expected efficacy or safety.
尽管使用了阿司匹林，但不良心血管事件仍有发生，这引发了人们对该药物可能存在抵抗性的关注。已经设定了几种定义，并且有多种实验室检测方法可用。这导致了不同临床实体中广泛的患病率报告。病因机制与临床、遗传和其他各种因素有关。这种现象的临床意义重大，值得关注。目前的管理策略仅限于改变剂量和引入其他抗血小板药物。然而，这些措施并未达到预期的疗效或安全性。
