Duffek L, Dabasi G
Semmelweis Orvostudományi Egyetem, Radiológiai Klinika, Budapest.
Orv Hetil. 1991 Feb 3;132(5):239-42.
Cyclosporin A treatment is unimaginable without continuous and periodical monitoring of the blood cyclosporin concentration. One of the best methods for measuring is the radioimmunoassay, because this method makes possible the monitoring of a large number of samples with good sensitivity. The method is suitable for measuring either only the cyclosporin A concentration (specific monoclonal antibody) or the cyclosporin A and its metabolites (nonspecific monoclonal antibody). The use of 125I labelled tracer has several advantages such as increased sensitivity, fast sample counting and so fast measuring of the concentrations.
如果不持续定期监测血液中环孢素的浓度，环孢素A治疗是不可想象的。最佳测量方法之一是放射免疫测定法，因为该方法能够以良好的灵敏度监测大量样本。该方法适用于仅测量环孢素A浓度（特异性单克隆抗体）或环孢素A及其代谢物（非特异性单克隆抗体）。使用125I标记的示踪剂有几个优点，如灵敏度提高、样本计数快以及浓度测量快。
