Castro C, Luengo-Oroz M A, Desnoulez S, Duloquin L, Fernandez-de-Manuel L, Montagna S, Ledesma-Carbayo M J, Bourgine P, Peyrieras N, Santos A
Biomedical Image Technologies, ETSIT, Universidad Politécnica de Madrid, Madrid 28040 Spain.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1469-72. doi: 10.1109/IEMBS.2009.5332436.
In order to properly understand and model the gene regulatory networks in animals development, it is crucial to obtain detailed measurements, both in time and space, about their gene expression domains. In this paper, we propose a complete computational framework to fulfill this task and create a 3D Atlas of the early zebrafish embryogenesis annotated with both the cellular localizations and the level of expression of different genes at different developmental stages. The strategy to construct such an Atlas is described here with the expression pattern of 5 different genes at 6 hours of development post fertilization.
为了正确理解和模拟动物发育过程中的基因调控网络，至关重要的是获取有关其基因表达域在时间和空间上的详细测量数据。在本文中，我们提出了一个完整的计算框架来完成这项任务，并创建一个早期斑马鱼胚胎发育的三维图谱，该图谱标注了不同发育阶段不同基因的细胞定位和表达水平。构建这样一个图谱的策略在此通过受精后6小时5种不同基因的表达模式进行描述。
